Liposome-entrapped superoxide dismutase reduces ischemia/reperfusion 'oxidative stress' in gerbil brain
| Autor: | Maria Spatz, Marina Markovic, Dejan V. Micic, B. B. Mršulja, Danica B. Stanimirovic |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Glutathione reductase Ischemia Brain Edema medicine.disease_cause Gerbil Biochemistry Brain ischemia Superoxide dismutase Lipid peroxidation Cellular and Molecular Neuroscience chemistry.chemical_compound Internal medicine medicine Animals biology business.industry Superoxide Dismutase Brain General Medicine medicine.disease Oxidative Stress Endocrinology Glutathione Reductase chemistry Ischemic Attack Transient Anesthesia Reperfusion Injury Liposomes biology.protein Lipid Peroxidation business Gerbillinae Reperfusion injury Oxidative stress |
| Zdroj: | Neurochemical research. 19(12) |
| ISSN: | 0364-3190 |
| Popis: | Bilateral common carotid artery occlusion (15 min.) followed by two hours of recirculation reduced mitochondrial superoxide dismutase (SOD) and glutathione reductase (GR) activities, and increased susceptibility of mitochondrial membranes to in vitro lipid peroxidation in brain regions (i.e., cortex, striatum and hippocampus) of Mongolian gerbil. Intraperitoneal bolus injection (2 mg/kg b.w.) of liposome-entrapped CuZn superoxide dismutase (l-SOD) increased the endogenous SOD activity in normal brain tissue and, when given at the end of ischemia, counteracted both the ischemic reduction of endogenous SOD and the increased peroxidation of mitochondrial membranes. 1-SOD treatment was ineffective in reducing brain swelling, suggesting that superoxide radicals are not a main participant in the process of (post)ischemic brain edema formation. |
| Databáze: | OpenAIRE |
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