Toxicogenetics: In Search of Host Susceptibility to Environmental Toxicants
| Autor: | Gelareh Alam, Byron C. Jones |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Carbamate
lcsh:QH426-470 Host (biology) Toxicogenetics medicine.medical_treatment Maneb Disease Rotenone Pesticide Biology Bioinformatics Reverse Genetic Analysis Mini Review Article chemistry.chemical_compound lcsh:Genetics Paraquat chemistry recombinant inbred strains Forward Genetic Analysis Genetics medicine Molecular Medicine Genetic resources Genetics (clinical) Systems genetics |
| Zdroj: | Frontiers in Genetics, Vol 5 (2014) Frontiers in Genetics |
| ISSN: | 1664-8021 |
| Popis: | Heavy metals, various pesticide and herbicides are implicated as risk factors for human health. Paraquat, maneb, and rotenone, carbamate, and organophosphorous insecticides are examples of toxicants for which acute and chronic exposure are associated with multiple neurological disorders including Parkinson’s disease. Nevertheless, the role of pesticide exposure in neurodegenerative diseases is not clear-cut, as there are inconsistencies in both the epidemiological and preclinical research. The aim of this short review is to show that at least, some of the inconsistencies are related to individual differences in susceptibility to the effects of neurotoxicants, individual differences that can be traced to the genetic constitution of the individuals and animals studies, i.e., host-based susceptibility. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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