Application of Silica-Supported Alkylating Reagents in a One-Pot, Sequential Protocol to Diverse Benzoxathiazepine 1,1-Dioxides
| Autor: | Paul R. Hanson, Thiwanka Bandara Samarakoon, Pradip K. Maity, Saqib Faisal, Robert L. Sourk, Qin Zang |
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| Rok vydání: | 2016 |
| Předmět: |
Alkylating Agents
Letter Alkylation Thiazepines one-pot Triazole Stereoisomerism 010402 general chemistry 01 natural sciences SNAr Phosphates chemistry.chemical_compound benzoxathiazepine 1 1-dioxides Nucleophilic aromatic substitution Benzyl Compounds Organic chemistry Amines 010405 organic chemistry Oxides Si-immobilized reagents General Chemistry General Medicine Triazoles Silicon Dioxide humanities 0104 chemical sciences chemistry Intramolecular force Reagent Indicators and Reagents |
| Zdroj: | ACS Combinatorial Science |
| ISSN: | 2156-8944 |
| Popis: | Applications of silica-ROMP reagents in a one-pot, sequential protocol have been developed for the synthesis of a variety of diverse benzoxathiazepine 1,1-dioxides. This protocol includes sulfonylation, intramolecular SNAr, alkylation with silica-supported oligomeric benzyl (Si-OBPn) and triazole (Si-OTPn) phosphates, and intermolecular SNAr addition with a number of secondary amines in one-pot to afford a variety of unique benzoxathiazepine 1,1-dioxides sultams in good to excellent yields. |
| Databáze: | OpenAIRE |
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