CTLA4 mediates antigen-specific apoptosis of human T cells
| Autor: | Cindy L. Jellis, E Greenfield, Paul D. Rennert, Gordon J. Freeman, John G. Gribben, Vassiliki A. Boussiotis, V A Restivo, X Ke, M Barber, Gary S. Gray |
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| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Interleukin 2
Immunoconjugates T-Lymphocytes Molecular Sequence Data HLA-DR7 Antigen Apoptosis Biology Cross Reactions Lymphocyte Activation Clonal deletion Abatacept Immune system CD28 Antigens Antigens CD medicine Cytotoxic T cell Humans CTLA-4 Antigen IL-2 receptor Amino Acid Sequence Phytohemagglutinins Receptor Cells Cultured Multidisciplinary Effector ZAP70 Antibodies Monoclonal Molecular biology Antigens Differentiation Cell biology Antigens Surface Interleukin-2 Cell Division Epitope Mapping medicine.drug Research Article |
| Popis: | The regulation of T cell-mediated immune responses requires a balance between amplification and generation of effector function and subsequent selective termination by clonal deletion. Although apoptosis of previously activated T cells can be induced by signaling of the tumor necrosis factor receptor family, these molecules do not appear to regulate T-cell clonal deletion in an antigen-specific fashion. We demonstrate that cross-linking of the inducible T-cell surface molecule CTLA4 can mediate apoptosis of previously activated human T lymphocytes. This function appears to be antigen-restricted, since a concomitant signal T-cell receptor signal is required. Regulation of this pathway may provide a novel therapeutic strategy to delete antigen-specific activated T cells. |
| Databáze: | OpenAIRE |
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