Serum TGF-Beta 1 and TNF-Alpha Levels and Cardiac Fibrosis in Experimental Chronic Renal Failure

Autor:	T. P. Ses, Rybakova Mg, J. C. MacMillan, S. B. Tkachenko, Anders Kallner, N. A. Gavrisheva, J. G. Vassilyeva, Alexey V. Fedulov
Rok vydání:	2005
Předmět:	medicine.medical_specialty biology business.industry Cardiac fibrosis Immunology General Medicine Transforming growth factor beta medicine.disease Cortex (botany) Endocrinology Fibrosis Internal medicine biology.protein medicine Chronic renal failure Tumor necrosis factor alpha business TGF beta 1 Serum markers
Zdroj:	Karolinska Institutet
ISSN:	1532-4311 0882-0139
Popis:	Objectives To characterize dynamics of changes of serum levels of TGF-β1 and TNF-α in rats with cardiac fibrosis (CF) occurring during chronic renal failure (CRF), and to reveal the character pf correlations of these factors with amounts of cardiac collagen. Design and Methods. CRF was induced by unilateral nephrectomy and by electrocoagulation of 25% of the cortex of remnant kidney. Post-operative checkpoints were 2, 4, and 6 months. Serum TGF-β1 and TNF-α levels were measured by ELISA. Results. CF became pronounced only at 6 months of CRF, while serum TGF-β1 concentrations reached maximum at 4 months, i.e., at the checkpoint preceding the development of CF. Multiple regression showed cardiac collagen to correlate with both serum TGF-β1 levels and time from the onset of CRF. Sensitivity and specificity of TGF-β1 as serum marker of CF were 86% and 75%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93db2d71ea12d7f8c119497e0e1bd66a https://doi.org/10.1081/imm-55807 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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