Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2:ERG fusion-positive versus fusion-negative tumors
| Autor: | Joshi J. Alumkal, Piet A. van den Brandt, Manuel Luedeke, Jian-Bing Fan, Irene M. Shui, Marina Bibikova, Janet L. Stanford, Brandy Klotzle, Ziding Feng, Milan S. Geybels, Christiane Maier, Elaine A. Ostrander, Antje E. Rinckleb, Shanshan Zhao |
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| Přispěvatelé: | Epidemiologie, RS: CAPHRI School for Public Health and Primary Care, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, RS: CAPHRI - R5 - Optimising Patient Care, RS: GROW - Oncology, RS: GROW - R1 - Prevention |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
BODY METHYLATION
RAB40C PDE4D Tumor tissue Fusion gene Prostate cancer 0302 clinical medicine DNA METHYLATION Genetics (clinical) Epigenomics Genetics 0303 health sciences TRIB2 REARRANGEMENTS GREM1 ASSOCIATION CpG site 3. Good health CACNA1D TARGET 030220 oncology & carcinogenesis ERG DNA methylation Epigenetics Unsupervised clustering ERG-EXPRESSION Gene fusion KLK10 Biology NT5C TMPRSS2 03 medical and health sciences Epigenomic profiling ST ARRAYS medicine SEPT9 Molecular Biology 030304 developmental biology C3orf14 Research mRNA expression TCGA IN-SITU HYBRIDIZATION medicine.disease HYPERMETHYLATION TISSUE Cancer research Developmental Biology |
| Zdroj: | Clinical epigenetics, 7:128. BioMed Central Ltd Clinical Epigenetics |
| ISSN: | 1868-7083 |
| Popis: | Background About half of all prostate cancers harbor the TMPRSS2:ERG (T2E) gene fusion. While T2E-positive and T2E-negative tumors represent specific molecular subtypes of prostate cancer (PCa), previous studies have not yet comprehensively investigated how these tumor subtypes differ at the epigenetic level. We therefore investigated epigenome-wide DNA methylation profiles of PCa stratified by T2E status. Results The study included 496 patients with clinically localized PCa who had a radical prostatectomy as primary treatment for PCa. Fluorescence in situ hybridization (FISH) “break-apart” assays were used to determine tumor T2E-fusion status, which showed that 266 patients (53.6 %) had T2E-positive PCa. The study showed global DNA methylation differences between tumor subtypes. A large number of differentially methylated CpG sites were identified (false-discovery rate [FDR] Q-value |
| Databáze: | OpenAIRE |
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