Glucose absorption, hormonal release and hepatic metabolism after guar gum ingestion
| Autor: | Kjell Malmlöf, C. Simoes Nunes |
|---|---|
| Přispěvatelé: | Revues Inra, Import |
| Rok vydání: | 1992 |
| Předmět: |
Dietary Fiber
Male medicine.medical_specialty Swine medicine.medical_treatment Gastric Inhibitory Polypeptide Biology Carbohydrate metabolism Galactans Absorption Mannans chemistry.chemical_compound Gastric inhibitory polypeptide Internal medicine [SDV.BDD] Life Sciences [q-bio]/Development Biology Plant Gums medicine Ingestion Animals Insulin Lactic Acid Insulin-Like Growth Factor I [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology Guar gum Lactic acid [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition Endocrinology Glucose Basal (medicine) chemistry Liver Lactates Blood Flow Velocity Blood sampling |
| Zdroj: | Reproduction, nutrition, development. 32(1) |
| ISSN: | 0926-5287 |
| Popis: | Six non-anaesthetized Large White pigs (mean body weight 59 +/- 1.7 kg) were fitted with permanent catheters in the portal vein, the brachiocephalic artery and the right hepatic vein and with electromagnetic flow probes around the portal vein and the hepatic artery. The animals were provided a basal none-fibre diet (diet A) alone or together with 6% guar gum (diet B) or 15% purified cellulose (diet C). The diets were given for 1 week and according to a replicated 3 x 3 latin-square design. On the last day of each adaptation period test meals of 800 g were given prior to blood sampling. The sampling was continued for 8 h. Guar gum strongly reduced the glucose absorption as well as the insulin, gastric inhibitory polypeptide (GIP) and insulin-like growth factor-1 (IGF-1) production. However, the reduction in peripheral blood insulin levels caused by guar gum was not associated with a change in hepatic insulin extraction. IGF-1 appeared to be strongly produced by the gut. The liver had a net uptake of the peptide. Ingestion of guar gum increased the hepatic extraction coefficient of gut produced IGF-1. Guar gum ingestion also appeared to decrease pancreatic glucagon secretion. Cellulose at the level consumed had very little effect on the parameters considered. It is suggested that the modulation of intestinal mechanisms by guar gum was sufficient to mediate the latter internal metabolic effects. |
| Databáze: | OpenAIRE |
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