Nicotinic acid adenine dinucleotide phosphate (NAADP) and Ca2+ mobilization
| Autor: | Judit Bak, Miklós Mándi |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Nicotinic acid adenine dinucleotide phosphate
Ryanodine receptor Cell chemistry.chemical_element Receptors Cell Surface Cell Biology Calcium Biology Biochemistry Ca2 mobilization chemistry.chemical_compound medicine.anatomical_structure chemistry Cytoplasm medicine Biophysics Extracellular Animals Humans Calcium Signaling Molecular Biology Oxidation-Reduction Intracellular NADP |
| Zdroj: | Journal of receptor and signal transduction research. 28(3) |
| ISSN: | 1079-9893 |
| Popis: | Many physiological processes are controlled by a great diversity of Ca2+ signals that depend on Ca2+ entry into the cell and/or Ca2+ release from internal Ca2+ stores. Ca2+ mobilization from intracellular stores is gated by a family of messengers including inositol-1,4,5-trisphosphate (InsP3), cyclic ADP-ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP). There is increasing evidence for a novel intracellular Ca2+ release channel that may be targeted by NAADP and that displays properties distinctly different from the well-characterized InsP3 and ryanodine receptors. These channels appear to localize on a wider range of intracellular organelles, including the acidic Ca2+ stores. Activation of the NAADP-sensitive Ca2+ channels evokes complex changes in cytoplasmic Ca2+ levels by means of channel chatter with other intracellular Ca2+ channels. The recent demonstration of changes in intracellular NAADP levels in response to physiologically relevant extracellular stimuli highlights the significance of NAADP as an important regulator of intracellular Ca2+ signaling. |
| Databáze: | OpenAIRE |
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