Influence of anaesthetics on rheology of human blood
| Autor: | Benjamin E. Etsten, H. Ben-Zion Aronson, Stanley E. Charm, Paul R. Levesque |
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| Rok vydání: | 1968 |
| Předmět: |
Cyclopropanes
Male business.industry Viscometer Blood Proteins General Medicine Hydrogen-Ion Concentration Apparent viscosity Blood Viscosity Blood proteins pCO2 Shear rate Hemoglobins Red blood cell Methoxyflurane Anesthesiology and Pain Medicine medicine.anatomical_structure Anesthesia medicine Shear stress Humans Hemorheology Halothane Rheology business |
| Zdroj: | Canadian Anaesthetists’ Society Journal. 15:244-257 |
| ISSN: | 1496-8975 0008-2856 |
| DOI: | 10.1007/bf03008737 |
| Popis: | Cyclopropane, halothane, and methoxyflurane were investigated for their effects on the viscometry of freshly drawn human blood (group O, Rh+). A total of 43 blood and 63 plasma samples containing specific anaesthetic agents were studied under controlled conditions of temperature, pH, Pco2, Po2, and red blood cell and plasma protein concentrations. A series of three cone plate viscometers, each with different shear rate ranges from 1500 to 6.75 sec.-1, was used. The Casson viscosity of blood and apparent plasma viscosity were determined from the slope of the shear stress-shear rate relationship plotted on a square root scale. Yield stress was determined by extrapolation from the shear stress axis intercept. Our findings indicate that the three anaesthetic agents, within concentrations equivalent to those used during clinical anaesthesia, caused no discernible effect on either yield stress or the apparent viscosity of blood or plasma. However, there was a marginal increase of the yield stress of blood with high concentrations of cyclopropane (above 20 mg.%) and a trend toward reduced plasma viscosity in all of the methoxyflurane samples. |
| Databáze: | OpenAIRE |
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