Neurochemical Enhancement of Conscious Error Awareness
| Autor: | L. Sanjay Nandam, Robert Hester, Mark A. Bellgrove, Redmond G O'Connell, Mark W. Strudwick, Joe Wagner, Jason B. Mattingley, Pradeep J. Nathan |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Time Factors Adolescent Consciousness Poison control Citalopram Neuropsychological Tests Cognitive neuroscience Atomoxetine Hydrochloride Gyrus Cinguli Young Adult Neurochemical Double-Blind Method Parietal Lobe Image Processing Computer-Assisted Reaction Time medicine Humans Attention deficit hyperactivity disorder Anterior cingulate cortex Analysis of Variance Brain Mapping Cross-Over Studies Propylamines Methylphenidate General Neuroscience Atomoxetine Articles Awareness medicine.disease Magnetic Resonance Imaging Oxygen Inhibition Psychological medicine.anatomical_structure Central Nervous System Stimulants Psychology Neuroscience Photic Stimulation medicine.drug Atomoxetine hydrochloride |
| Zdroj: | The Journal of Neuroscience. 32:2619-2627 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.4052-11.2012 |
| Popis: | How the brain monitors ongoing behavior for performance errors is a central question of cognitive neuroscience. Diminished awareness of performance errors limits the extent to which humans engage in corrective behavior and has been linked to loss of insight in a number of psychiatric syndromes (e.g., attention deficit hyperactivity disorder, drug addiction). These conditions share alterations in monoamine signaling that may influence the neural mechanisms underlying error processing, but our understanding of the neurochemical drivers of these processes is limited. We conducted a randomized, double-blind, placebo-controlled, cross-over design of the influence of methylphenidate, atomoxetine, and citalopram on error awareness in 27 healthy participants. The error awareness task, a go/no-go response inhibition paradigm, was administered to assess the influence of monoaminergic agents on performance errors during fMRI data acquisition. A single dose of methylphenidate, but not atomoxetine or citalopram, significantly improved the ability of healthy volunteers to consciously detect performance errors. Furthermore, this behavioral effect was associated with a strengthening of activation differences in the dorsal anterior cingulate cortex and inferior parietal lobe during the methylphenidate condition for errors made with versus without awareness. Our results have implications for the understanding of the neurochemical underpinnings of performance monitoring and for the pharmacological treatment of a range of disparate clinical conditions that are marked by poor awareness of errors. |
| Databáze: | OpenAIRE |
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