Serum vitamin D and hippocampal gray matter volume in schizophrenia
| Autor: | Matcheri S. Keshavan, Sri Mahavir Agarwal, Janardhanan C. Narayanaswamy, Ganesan Venkatasubramanian, Sunil V. Kalmady, Anekal C. Amaresha, Venkataram Shivakumar, Boban Joseph, Vasanthapuram Ravi, Dania Jose, Bangalore N. Gangadhar |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Statistics as Topic Neuroscience (miscellaneous) Hippocampal formation Hippocampus vitamin D deficiency Pathogenesis Risk Factors Internal medicine medicine Vitamin D and neurology Humans Radiology Nuclear Medicine and imaging Gray Matter Vitamin D Serum vitamin medicine.diagnostic_test biology Magnetic resonance imaging Organ Size Vitamin D Deficiency medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Serum vitamin D level Endocrinology Schizophrenia biology.protein Receptors Calcitriol Female Psychology Neurotrophin |
| Zdroj: | Psychiatry Research: Neuroimaging. 233:175-179 |
| ISSN: | 0925-4927 |
| Popis: | Disparate lines of evidence including epidemiological and case-control studies have increasingly implicated vitamin D in the pathogenesis of schizophrenia. Vitamin D deficiency can lead to dysfunction of the hippocampus--a brain region hypothesized to be critically involved in schizophrenia. In this study, we examined for potential association between serum vitamin D level and hippocampal gray matter volume in antipsychotic-naïve or antipsychotic-free schizophrenia patients (n = 35). Serum vitamin D level was estimated using 25-OH vitamin D immunoassay. Optimized voxel-based morphometry was used to analyze 3-Tesla magnetic resonance imaging (MRI) (1-mm slice thickness). Ninety-seven percent of the schizophrenia patients (n = 34) had sub-optimal levels of serum vitamin D (83%, deficiency; 14%, insufficiency). A significant positive correlation was seen between vitamin D and regional gray matter volume in the right hippocampus after controlling for age, years of education and total intracranial volume (Montreal Neurological Institute (MNI) coordinates: x = 35, y = -18, z = -8; t = 4.34 pFWE(Corrected) = 0.018). These observations support a potential role of vitamin D deficiency in mediating hippocampal volume deficits, possibly through neurotrophic, neuroimmunomodulatory and glutamatergic effects. |
| Databáze: | OpenAIRE |
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