Predictive Factors of Severe Behçet's disease: A Longitudinal, Prospective Cohort Followed Between 1981–2020
| Autor: | Luísa Serpa Pinto, Sara Xavier Pires, Berta Silva, Fátima Farinha, Carlos Vasconcelos, João Araújo Correia |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Male
Erythema nodosum medicine.medical_specialty business.industry Behcet Syndrome Mucocutaneous zone General Medicine Behcet's disease medicine.disease Cohort Studies Erythema Nodosum Rheumatology Internal medicine Cohort medicine Humans Outpatient clinic Female Prospective Studies Age of Onset Prospective cohort study business Vasculitis Cohort study |
| Zdroj: | Reumatología Clínica. 18:410-415 |
| ISSN: | 1699-258X |
| Popis: | INTRODUCTION Behcet's disease (BD) is a systemic vasculitis of unknown cause. The spectrum of the disease ranges from mucocutaneous manifestations to other organ diseases with relevant morbidity. Associations between disease severity and male sex, earlier age at onset, and the presence of erythema nodosum have been described. OBJECTIVES To evaluate clinical factors associated with manifestations of severe disease in a single-center cohort. METHODS A longitudinal, prospective, unicentric cohort study with patients followed in a specialized outpatient clinic between 1981 and 2020. Severe BD was defined as a Krause total clinical severity score >4 points. RESULTS We included 243 patients, of whom 31% were male, with an average follow-up time of 14.6 years. Regarding organ manifestations, all patients had mucous manifestations (N=243, 100%), 133 (55%) skin, 104 (43%) joint, 71 (29%) ocular, 48 (20%) vascular, 47 (19%) neurological, 22 (9%) gastrointestinal and 1 (0.4%) cardiac involvement by BD. One hundred fifty-six (64%) patients were classified as having severe BD. Severe BD was more frequent in men (OR=2.004, p=0.024), increasing with age (OR=1.021 per year, p=0.037), in the presence of skin manifestations (OR=4.711, p |
| Databáze: | OpenAIRE |
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