An fNIRS investigation of associative recognition in the prefrontal cortex with a rapid event-related design
| Autor: | Amarnath Yennu, Heekyeong Park, Hanli Liu, James D. Schaeffer, Fenghua Tian, Kellen Gandy |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Ventrolateral prefrontal cortex Adolescent Prefrontal Cortex Neuropsychological Tests Cognitive neuroscience Young Adult medicine Humans Prefrontal cortex Associative property Spectroscopy Near-Infrared medicine.diagnostic_test General Neuroscience Hemodynamics Association Learning Recognition Psychology Signal Processing Computer-Assisted Cognition Content-addressable memory Dorsolateral prefrontal cortex medicine.anatomical_structure Pattern Recognition Visual Reading Cerebrovascular Circulation Linear Models Female Psychology Functional magnetic resonance imaging Cognitive psychology |
| Zdroj: | Journal of Neuroscience Methods. 235:308-315 |
| ISSN: | 0165-0270 |
| DOI: | 10.1016/j.jneumeth.2014.07.011 |
| Popis: | Background Functional near-infrared spectroscopy (fNIRS) measures hemodynamic changes at the cortical level. The use of fNIRS is growing in popularity for studying cognitive neuroscience in which event-related designs are widely used with functional magnetic resonance imaging (fMRI). However, the applicability of event-related designs with fNIRS has not been fully understood. Therefore, the present study employed fNIRS with a rapid-presentation event-related design for investigating prefrontal cortical activity during complex associative recognition. New method Participants studied a list of word pairs and were later given an associative recognition test. Throughout the experiment, each event was presented rapidly (∼4 s). Data were sorted based on accuracy of associative memory judgments and analyzed using the general linear model (GLM) with an event-related design. Results During retrieval, significant increases in oxygenated hemoglobin concentrations were observed in dorsolateral and ventrolateral prefrontal regions for successful associative recognition. When comparing retrieval to encoding, significant increases in oxygenated hemoglobin concentrations were also observed in dorsolateral prefrontal cortex. Comparison with existing method The current fNIRS results corroborate previous fMRI findings that have demonstrated the involvement of dorsolateral and ventrolateral prefrontal cortex in associative recognition. Therefore, the present study validates versatile use of fNIRS with a rapid-presentation event-related design in the investigation of neural mechanisms of associative memory. Conclusion The findings of this study provide evidence that fNIRS can be a viable research method for investigating complex cognitive processes commonly of interest in cognitive neuroscience. Taken together, these results demonstrate that fNIRS can be a cost-effective and accessible experimental tool for cognitive neuroscience. |
| Databáze: | OpenAIRE |
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