Maturation of glutamatergic transmission in the vestibulo-olivary pathway impacts on the registration of head rotational signals in the brainstem of rats
| Autor: | Chun-Wai Ma, Kelvin W.K. Yeung, Suk-King Lai, Lei Han, Daisy K.Y. Shum, C.H. Lai, Hoi-Man Wong, YS Chan |
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| Rok vydání: | 2014 |
| Předmět: |
Male
0301 basic medicine Histology Rotation Glutamic Acid Olivary Nucleus Stimulus (physiology) Biology Reticular formation Receptors N-Methyl-D-Aspartate Rats Sprague-Dawley 03 medical and health sciences Glutamatergic 0302 clinical medicine Vestibular nuclei Neural Pathways otorhinolaryngologic diseases Animals Neurons Vestibular system Prepositus hypoglossal nucleus Reticular Formation General Neuroscience Glutamate receptor Excitatory Postsynaptic Potentials Anatomy Vestibular Nuclei Semicircular Canals Rats 030104 developmental biology Female Vestibule Labyrinth sense organs Brainstem Dizocilpine Maleate Excitatory Amino Acid Antagonists Proto-Oncogene Proteins c-fos Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Brain Structure and Function. 221:217-238 |
| ISSN: | 1863-2661 1863-2653 |
| Popis: | The recognition of head orientation in the adult involves multi-level integration of inputs within the central vestibular circuitry. How the different inputs are recruited during postnatal development remains unclear. We hypothesize that glutamatergic transmission at the vestibular nucleus contributes to developmental registration of head orientations along the vestibulo-olivary pathway. To investigate the maturation profile by which head rotational signals are registered in the brainstem, we used sinusoidal rotations on the orthogonal planes of the three pairs of semicircular canals. Fos expression was used as readout of neurons responsive to the rotational stimulus. Neurons in the vestibular nucleus and prepositus hypoglossal nucleus responded to all rotations as early as P4 and reached adult numbers by P21. In the reticular formation and inferior olive, neurons also responded to horizontal rotations as early as P4 but to vertical rotations not until P21 and P25, respectively. Neuronal subpopulations that distinguish between rotations activating the orthogonally oriented vertical canals were identifiable in the medial and spinal vestibular nuclei by P14 and in the inferior olivary subnuclei IOβ and IOK by P25. Neonatal perturbation of glutamate transmission in the vestibular nucleus was sufficient to derange formation of this distribution in the inferior olive. This is the first demonstration that developmental refinement of glutamatergic synapses in the central vestibular circuitry is essential for developmental registration of head rotational signals in the brainstem. |
| Databáze: | OpenAIRE |
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