Effects of vestibular training on motion sickness, nystagmus, and subjective vertical
| Autor: | Olivier Deguine, Gilles Clément, Mathieu Bourg, Anne Pavy-LeTraon |
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| Přispěvatelé: | Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Service d'oto-rhino-laryngologie, Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Marlot, Catherine, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut des sciences du cerveau de Toulouse. (ISCT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Beaujon-Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) |
| Rok vydání: | 2008 |
| Předmět: |
Male
Motion sickness genetic structures MESH: Motion Sickness adaptation Nystagmus Audiology MESH: Rotation 0302 clinical medicine Habituation 030223 otorhinolaryngology Vestibular system Acetylleucine General Neuroscience MESH: Posture habituation MESH: Nystagmus Physiologic Sensory Systems vestibulo-ocular reflex 030220 oncology & carcinogenesis [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Vestibule Labyrinth medicine.symptom Psychology medicine.drug Adult MESH: Habituation Psychophysiologic medicine.medical_specialty Rotation Posture Smooth pursuit 03 medical and health sciences Nystagmus Physiologic Leucine otorhinolaryngologic diseases medicine Humans [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Habituation Psychophysiologic MESH: Humans acetylleucine MESH: Adult Optokinetic reflex medicine.disease MESH: Male MESH: Leucine Otorhinolaryngology sense organs Neurology (clinical) Vestibulo–ocular reflex MESH: Vestibule Labyrinth |
| Zdroj: | HAL Journal of Vestibular Research Journal of Vestibular Research, IOS Press, 2007, 17 (5-6), pp.227-37 |
| ISSN: | 1878-6464 0957-4271 |
| DOI: | 10.3233/ves-2007-175-604 |
| Popis: | International audience; Pitch head-and-trunk movements during constant velocity rotation are a provocative vestibular stimulus that produces vertigo and nausea. When exposed to this stimulus repeatedly, motion sickness symptoms diminish as the subjects habituate. Acetylleucine is a drug that is used to treat acute vestibular vertigo. In this study, we wanted to ascertain whether this drug (a) lessened motion sickness or delayed habituation; (b) accelerated the recovery following habituation; and (c) whether changes in the subjective vertical accompanied habituation. Twenty subjects were administered acetylleucine or placebo in a double-blind study during a five-day vestibular training. Horizontal vestibulo-ocular reflex, optokinetic nystagmus, smooth pursuit, and subjective visual vertical were evaluated before, during, and up to two months after the vestibular training. Based on Graybiel's diagnostic criteria, motion sickness decreased steadily in each vestibular training session, and there was no difference between the scores in the acetylleucine and placebo groups. Post-rotatory nystagmus peak velocity and time constant also declined in both groups at the same rate. Thus, acetylleucine neither reduced the nausea associated with this provocative stimulus, nor hastened the acquisition or retention of vestibular habituation of motion sickness and nystagmus. There was no difference in optokinetic nystagmus and smooth pursuit between the acetylleucine and placebo groups. However, subjects showed larger error in the subjective visual vertical after habituation, which indicates that spatial orientation is also affected by vestibular training. |
| Databáze: | OpenAIRE |
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