Dengue score: a proposed diagnostic predictor for pleural effusion and/or ascites in adults with dengue infection
| Autor: | R. Tedjo Sasmono, Leonard Nainggolan, Maulana Suryamin, Eppy Ibrahim, Bonita Effendi, Suhendro Suwarto, Robert Sinto |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Pathology Multivariate analysis Pleural effusion Plasma leakage Hematocrit Severity of Illness Index Dengue fever Hemoglobins 0302 clinical medicine Ascites Medicine 030212 general & internal medicine Prospective Studies Child medicine.diagnostic_test Platelet Exudates and Transudates Middle Aged Infectious Diseases Female medicine.symptom Research Article Adult medicine.medical_specialty Adolescent 030231 tropical medicine Sensitivity and Specificity World health 03 medical and health sciences Young Adult AST ratio Dengue score Predictive Value of Tests Internal medicine Humans Severe Dengue Serum Albumin Aged business.industry Platelet Count Albumin medicine.disease Indonesia Multivariate Analysis Observational study business |
| Zdroj: | BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| Popis: | Background There are several limitations in diagnosing plasma leakage using the World Health Organization (WHO) guidelines of dengue hemorrhagic fever. We conducted a study to develop a dengue scoring system to predict pleural effusion and/or ascites using routine laboratory parameters. Methods A prospective observational study was carried out at Cipto Mangunkusumo Hospital and Persahabatan Hospital, Jakarta, Indonesia. Dengue-infected adults admitted on the third febrile day from March, 2010 through August, 2015 were included in the study. A multivariate analysis was conducted to determine the independent diagnostic predictors of pleural effusion and/or ascites and to convert the prediction model into a scoring system. Results A total of 172 dengue-infected adults were enrolled in the study. Of the 172 patients, 101 (58.7 %) developed pleural effusion and/or ascites. A multivariate analysis was conducted to determine the independent diagnostic predictors of pleural effusion and/or ascites in dengue-infected adults. The predictors were scored based on the following calculations: hemoconcentration ≥15.1 % had a score of 1 (OR, 3.11; 95 % CI, 1.41–6.88), lowest albumin concentration at critical phase ≤3.49 mg/dL had a score of 1 (OR, 4.48; 95 % CI, 1.87–10.77), lowest platelet count ≤49,500/μL had a score of 1 (OR, 3.62; 95 % CI, 1.55–8.49), and elevated ratio of AST ≥2.51 had a score of 1 (OR 2.67; 95 % CI, 1.19–5.97). At a cut off of ≥ 2, the Dengue Score predicted pleural effusion and/or ascites diagnosis with positive predictive value of 79.21 % and negative predictive value of 74.63 %. This prediction model is suitable for calibration and good discrimination. Conclusions We have developed a Dengue Score that could be used to identify pleural effusion and/or ascites and might be useful to stratify dengue-infected patients at risk for developing severe dengue. |
| Databáze: | OpenAIRE |
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