Longitudinal Assessment of Airway Caliber and Responsiveness in Workers Exposed to Chlorine
| Autor: | Jean-Guy Dufour, Denyse Gautrin, Jean-Luc Malo, H Ghezzo, Christophe Leroyer, Denise Girard, Claire Infante-Rivard |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Spirometry Longitudinal study medicine.medical_specialty Vital Capacity Occupational disease Critical Care and Intensive Care Medicine Bronchial Provocation Tests Bronchoconstrictor Agents FEV1/FVC ratio Forced Expiratory Volume Occupational Exposure Accidents Occupational Humans Medicine Longitudinal Studies Risk factor Methacholine Chloride Inhalation exposure Inhalation Exposure Inhalation medicine.diagnostic_test business.industry Smoking Middle Aged Respiration Disorders medicine.disease respiratory tract diseases Surgery Anesthesia Metallurgy Female Bronchial Hyperreactivity Chlorine business Airway Follow-Up Studies |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 160:1232-1237 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/ajrccm.160.4.9811074 |
| Popis: | This longitudinal study (1992-1994) was performed to determine the relation between accidental chlorine exposure and changes in lung function and airway responsiveness in 239 workers in a metal production plant. These workers had taken part in a cross-sectional survey in 1992. In both the initial and the follow-up surveys, history of exposure to chlorine ("puffs"), accidental chlorine inhalation reported to the first-aid unit (gassing incidents), and of chronic symptoms were documented; spirometry and methacholine challenge tests were performed. At follow-up, 211 workers (88.3%) were seen. In workers with 20 pack-years or more of cigarette smoking, the fall in FEV(1) was associated with having had a gassing incident during the follow-up period; the fall in FEV(1)/FVC (%) was predicted by the number of puffs causing mild symptoms between the two assessments. An increase in airway responsiveness (PC(20) decrease > 1.5-fold) was present in 19 workers; it was associated with accidents reported to the first-aid unit during the previous 2 yr (OR: 5.9, 95% CI: 1.1 to 32.3). These findings suggest: (1) an effect on airway function related to the estimated number of puffs with mild symptoms and gassing incidents, mostly among smokers; (2) a detectable increase in airway responsiveness associated with gassing incidents. |
| Databáze: | OpenAIRE |
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