Discordant rifampicin susceptibility results are associated with Xpert® MTB/RIF probe B and probe binding delay

Autor: Christopher K Lippincott, Cynthia Firnhaber, Rebecca Berhanu, Karen R. Jacobson, R Kularatne, Kathryn Schnippel, C. R. Horsburgh
Rok vydání: 2019
Předmět:
Oncology
0301 basic medicine
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Tuberculosis
Total cost
030106 microbiology
Developing country
Rifampicin resistance
Family income
Mycobacterium tuberculosis
03 medical and health sciences
0302 clinical medicine
Internal medicine
Environmental health
polycyclic compounds
medicine
heterocyclic compounds
030212 general & internal medicine
Young adult
health care economics and organizations
Retrospective review
biology
business.industry
Drug resistant tuberculosis
Diagnostic test
Retrospective cohort study
Drug susceptibility
biochemical phenomena
metabolism
and nutrition
bacterial infections and mycoses
biology.organism_classification
medicine.disease
Infectious Diseases
Cost of treatment
bacteria
Household income
business
Rifampicin
medicine.drug
Zdroj: The International Journal of Tuberculosis and Lung Disease. 23:358-362
ISSN: 1027-3719
DOI: 10.5588/ijtld.17.0837
Popis: Setting Ethiopia has a high prevalence of tuberculosis (TB) and is one of the countries with the highest burden of multidrug-resistant TB (MDR-TB). Objective To understand the costs that patients incur in obtaining diagnosis and treatment for MDR-TB. Design In March 2013, interviews were conducted with 169 MDR-TB patients at three hospitals in Ethiopia to identify the cost to patients and the impact on employment and family income. Results The average MDR-TB patient incurred a total cost of US$1378, which represented 25 months of a mid-treatment household income of US$54. The impact on the patient's employment and on overall patient and family income was generally catastrophic: 74% of all respondents reported losing their jobs, 66% of patients lost household income, and household income was reduced by 38%. To help cover the costs, 38% of patients sold some type of property, while 7% leased out property and 41% took out loans, any of which could jeopardize their future financial situation even further. Conclusion Despite services being officially free of charge, most patients incurred catastrophic costs and suffered significant income loss as a result of obtaining diagnosis and treatment for MDR-TB.
Databáze: OpenAIRE
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