Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

Autor: Nichelle I. Winters, Taylor Adams, Jessica B. Blackburn, Mei-I Chung, Andrew G. Nicholson, William A Wallace, Bradley W. Richmond, Naftali Kaminski, Jonas C. Schupp, Sergio Poli, Linh T. Bui, Austin J. Gutierrez, Lance M. Peter, Chase J. Taylor, Chitra Joseph, Ivan O. Rosas, Jonathan A. Kropski, R. Gisli Jenkins, Arun C. Habermann, Doris Rassl, Nicholas E. Banovich
Přispěvatelé: Groningen Research Institute for Asthma and COPD (GRIAC), Bui, Linh T [0000-0003-3152-8978], Joseph, Chitra [0000-0003-2631-9266], Gutierrez, Austin J [0000-0003-2977-2189], Schupp, Jonas C [0000-0002-7714-8076], Poli, Sergio [0000-0001-5442-3189], Richmond, Bradley W [0000-0001-6200-5235], Wallace, William A [0000-0002-4752-7956], Jenkins, R Gisli [0000-0002-7929-2119], Kaminski, Naftali [0000-0001-5917-4601], Apollo - University of Cambridge Repository
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Lung Diseases
General Physics and Astronomy
medicine.disease_cause
Virus Replication
Transcriptome
0302 clinical medicine
Pulmonary fibrosis
Gene expression
Lung
Coronavirus
COPD
Multidisciplinary
respiratory system
medicine.anatomical_structure
030220 oncology & carcinogenesis
RECEPTOR ACE2
Angiotensin-Converting Enzyme 2
congenital
hereditary
and neonatal diseases and abnormalities
Immunopathogenesis
Science
Article
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Immune system
Immunity
medicine
Humans
Inflammation
Innate immune system
business.industry
SARS-CoV-2
COVID-19
General Chemistry
Virus Internalization
medicine.disease
Idiopathic Pulmonary Fibrosis
Immunity
Innate
Computational biology and bioinformatics
respiratory tract diseases
030104 developmental biology
Viral replication
Viral infection
Alveolar Epithelial Cells
Immunology
Chronic Disease
business
Zdroj: Nature Communications, 12(1):4314. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
ISSN: 2041-1723
Popis: Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 (COVID-19) and poor outcomes. Here, we analyze the transcriptomes of 611,398 single cells isolated from healthy and CLD lungs to identify molecular characteristics of lung cells that may account for worse COVID-19 outcomes in patients with chronic lung diseases. We observe a similar cellular distribution and relative expression of SARS-CoV-2 entry factors in control and CLD lungs. CLD AT2 cells express higher levels of genes linked directly to the efficiency of viral replication and the innate immune response. Additionally, we identify basal differences in inflammatory gene expression programs that highlight how CLD alters the inflammatory microenvironment encountered upon viral exposure to the peripheral lung. Our study indicates that CLD is accompanied by changes in cell-type-specific gene expression programs that prime the lung epithelium for and influence the innate and adaptive immune responses to SARS-CoV-2 infection.
Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 and poor outcomes. Here the authors compare the transcriptomes of single cells isolated from healthy and CLD lungs to identify molecular characteristics of lung cells that may account for worse COVID-19 outcomes in these patients.
Databáze: OpenAIRE
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