Relation of body mass index with carotid intima-media thickness and diameter is independent of metabolic syndrome in postmenopausal Mediterranean women
Autor: | G. Covetti, Gabriella Iannuzzo, Mario De Michele, Arcangelo Iannuzzi, Amalia Mattiello, Paolo Rubba, Marco Gentile, Salvatore Panico |
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Rok vydání: | 2012 |
Předmět: |
medicine.medical_specialty
Population Overweight Carotid Intima-Media Thickness Body Mass Index Cohort Studies Internal medicine Prevalence medicine Humans Obesity education Aged Metabolic Syndrome education.field_of_study business.industry Obstetrics and Gynecology Odds ratio Middle Aged medicine.disease Postmenopause Carotid Arteries Logistic Models Blood pressure Italy Intima-media thickness Cardiology Female medicine.symptom Metabolic syndrome business Body mass index |
Zdroj: | Menopause. 19:1104-1108 |
ISSN: | 1072-3714 |
Popis: | OBJECTIVE The aim of this study was to evaluate whether overweight and obesity are associated with arterial abnormalities in postmenopausal women and the contribution of the metabolic syndrome. METHODS A total of 390 postmenopausal women (mean age, 63.1 ± 7.7 y) living in the metropolitan area of Naples, Southern Italy, and participating in a population-based cohort study (Progetto Atena) were offered an ultrasound examination of the carotid arteries; 370 women accepted. Blood pressure, serum high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, fasting glucose, insulin, apolipoprotein B, and high-sensitivity C-reactive protein were measured in all participants. RESULTS Women in the second and third tertiles of body mass index showed a greater common carotid intima-media thickness compared with those in the first tertile (tertile II vs I, odds ratio, 2.15; P = 0.013; tertile III vs I, odds ratio, 2.24; P = 0.018), adjusted for age and metabolic syndrome. Obese and overweight postmenopausal women showed greater common carotid lumen diameters as compared with lean postmenopausal women (mean ± SD, 6.36 ± 0.86, 6.16 ± 0.65, and 5.96 ± 0.59 mm, respectively; P < 0.001 [obese vs lean] and P = 0.04 [overweight vs lean]); no statistical difference in carotid lumen diameter was found between obese and overweight postmenopausal women. The statistical significance between obese and lean postmenopausal women was retained even after adding the components of the metabolic syndrome as covariates. CONCLUSIONS These findings indicate an association between overweight, obesity, and preclinical carotid artery abnormalities, independently of the metabolic syndrome, in a population of postmenopausal women. |
Databáze: | OpenAIRE |
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