A randomized phase III study comparing three anthracycline-free taxane-based regimens, as first line chemotherapy, in metastatic breast cancer: a Hellenic Cooperative Oncology Group study
| Autor: | Anna Kalogera-Fountzila, Christos Papadimitriou, Epaminontas Samantas, Dimitris Bafaloukos, E. Briasoulis, Maria Karina, Urania Dafni, Nikos Maniadakis, George Fountzilas, H. P. Kalofonos, Meletios A. Dimopoulos, Angelos Koutras, Gerassimos Aravantinos, P. Kosmidis, D.V. Skarlos, D.G. Pectasides, F. Matsiakou, Helen Gogas, Pavlos Papakostas, C. Christodoulou |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Oncology
Cancer Research medicine.medical_treatment Paclitaxel/administration & dosage/therapeutic use Docetaxel Deoxycytidine Carboplatin chemistry.chemical_compound Carboplatin/therapeutic use Antineoplastic Combined Chemotherapy Protocols Neoplasm Metastasis Aged 80 and over Antibodies Monoclonal Middle Aged Metastatic breast cancer Taxoids/administration & dosage/*therapeutic use Breast Neoplasms/*drug therapy/*pathology Taxoids Female medicine.drug Adult medicine.medical_specialty Paclitaxel Antineoplastic Agents Breast Neoplasms Antibodies Monoclonal/therapeutic use Antibodies Monoclonal Humanized Breast cancer Internal medicine medicine Deoxycytidine/administration & dosage/analogs & derivatives Humans Aged Chemotherapy Taxane Performance status business.industry Antineoplastic Agents/therapeutic use Trastuzumab medicine.disease Gemcitabine Surgery chemistry Antineoplastic Combined Chemotherapy Protocols/therapeutic use business |
| Popis: | BACKGROUND: Effective anthracycline-free combinations need to be evaluated in metastatic breast cancer (MBC), due to the increased number of patients treated with anthracycline-based adjuvant chemotherapy. PATIENTS AND METHODS: Patients with MBC were randomized to paclitaxel and carboplatin (PCb) every 3 weeks or docetaxel and gemcitabine (GDoc) every 3 weeks or weekly paclitaxel (Pw). Trastuzumab was given to patients with HER-2 over-expressing tumors. The primary endpoint of the study was survival. Quality of life (QoL) and cost were assessed. RESULTS: Totally, 416 eligible patients entered the study. Median survival times were 29.9 months for PCb, 26.9 for GDoc and 41.0 for Pw (P = 0.037). According to multivariate analysis, adjuvant chemotherapy, >1 metastatic sites, lack of maintenance hormonal therapy, and worse performance status (PS) were significant adverse prognostic factors for survival, while Pw when compared to GDoc improved survival (P = 0.03), as well as when compared to PCb in the subgroup of patients with PS = 1 (P = 0.01, treatment by PS interaction P = 0.03). No significant differences in terms of time to progression were found. Severe myelotoxicity and mucositis were more frequent with GDoc, while severe neuropathy with PCb and Pw. QoL changes did not differ significantly between treatment groups, while cost analysis favored Pw. CONCLUSIONS: Pw appears to be the most preferable choice among the 3 anthracycline-free taxanes-based regimens tested in the present study. Breast Cancer Res Treat |
| Databáze: | OpenAIRE |
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