Bioactive hydroxyphenylpyrrole-dicarboxylic acids from a new marine Halomonas sp.: production and structure elucidation
| Autor: | T. Groβe, Siegmund Lang, L. Liang, G. Bach, Heike Stevens, J. Bitzer, Meinhard Simon, Thorsten Brinkhoff, Harukuni Tokuda, Axel Zeeck, Linzhu Wang |
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| Rok vydání: | 2006 |
| Předmět: |
chemistry.chemical_classification
Halomonas biology Artificial seawater Antineoplastic Agents General Medicine biology.organism_classification Applied Microbiology and Biotechnology Halomonadaceae chemistry.chemical_compound Dicarboxylic acid chemistry Biochemistry Tryptone Glycine Anticarcinogenic Agents Yeast extract Dicarboxylic Acids Food science Bacteria Biotechnology |
| Zdroj: | Applied Microbiology and Biotechnology. 72:816-822 |
| ISSN: | 1432-0614 0175-7598 |
| DOI: | 10.1007/s00253-006-0370-1 |
| Popis: | The new marine Halomonas sp. strain GWS-BW-H8hM (DSM 17996) was found to produce 3-(4'-hydroxyphenyl)-4-phenylpyrrole-2,5-dicarboxylic acid (HPPD-1) and 3,4-bis(4'-hydroxy- phenyl)pyrrole-2,5-dicarboxylic acid (HPPD-2). In initial cultivations using marine broth, only low contents of these compounds have been isolated. Improving the conditions and growing the strain on artificial seawater supplemented with tryptone 10 g l(-1), yeast extract 5 g l(-1), L-tyrosine 0.6 g l(-1), glycine 1 g l(-1), and glucose 6 g l(-1), the growth-associated HPPD-1 and HPPD-2 production of a 40-l batch cultivation reached the amounts of 47 mg l(-1) and 116 mg l(-1), respectively, after 65 h. Both compounds showed potent anti-tumor-promoting activities. |
| Databáze: | OpenAIRE |
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