Non-invasive electrical brain stimulation for vision restoration after stroke: An exploratory randomized trial (REVIS)
| Autor: | Carolin Borrmann, Ariel Schoenfeld, Bernhard A. Sabel, Lizbeth Cárdenas-Morales, Katri Silvennoinen, Paolo Maria Rossini, Giuseppe Granata, Michael Sailer, Andrea Antal, Juha M. Holopainen, Silja Räty, Francesca de Rossi, Turgut Tatlisumak |
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| Přispěvatelé: | HUS Neurocenter, Neurologian yksikkö, University of Helsinki, HUS Head and Neck Center, Silmäklinikka |
| Rok vydání: | 2021 |
| Předmět: |
030506 rehabilitation
genetic structures business.operation medicine.medical_treatment Transcranial Direct Current Stimulation 3124 Neurology and psychiatry law.invention ALTERNATING-CURRENT STIMULATION 0302 clinical medicine Randomized controlled trial law PLASTICITY occipital stroke Stroke Transcranial direct-current stimulation Stroke Rehabilitation Brain RECOVERY Visual field VISUAL FUNCTION medicine.anatomical_structure Neurology Optic nerve SENSITIVITY 0305 other medical science Transorbital Electrical brain stimulation Research Article medicine.medical_specialty rehabilitation 03 medical and health sciences Physical medicine and rehabilitation Developmental Neuroscience medicine Humans HEMIANOPIA FIELD Vision Ocular business.industry 3112 Neurosciences medicine.disease eye diseases Visual cortex Electrical stimulation randomized controlled trial Hemianopsia homonymous hemianopia vision restoration Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Restorative Neurology and Neuroscience |
| ISSN: | 1878-3627 0922-6028 |
| Popis: | Background: Occipital strokes often cause permanent homonymous hemianopia leading to significant disability. In previous studies, non-invasive electrical brain stimulation (NIBS) has improved vision after optic nerve damage and in combination with training after stroke. Objective: We explored different NIBS modalities for rehabilitation of hemianopia after chronic stroke. Methods: In a randomized, double-blinded, sham-controlled, three-armed trial, altogether 56 patients with homonymous hemianopia were recruited. The three experiments were: i) repetitive transorbital alternating current stimulation (rtACS, n = 8) vs. rtACS with prior cathodal transcranial direct current stimulation over the intact visual cortex (tDCS/rtACS, n = 8) vs. sham (n = 8); ii) rtACS (n = 9) vs. sham (n = 9); and iii) tDCS of the visual cortex (n = 7) vs. sham (n = 7). Visual functions were evaluated before and after the intervention, and after eight weeks follow-up. The primary outcome was change in visual field assessed by high-resolution and standard perimetries. The individual modalities were compared within each experimental arm. Results: Primary outcomes in Experiments 1 and 2 were negative. Only significant between-group change was observed in Experiment 3, where tDCS increased visual field of the contralesional eye compared to sham. tDCS/rtACS improved dynamic vision, reading, and visual field of the contralesional eye, but was not superior to other groups. rtACS alone increased foveal sensitivity, but was otherwise ineffective. All trial-related procedures were tolerated well. Conclusions: This exploratory trial showed safety but no main effect of NIBS on vision restoration after stroke. However, tDCS and combined tDCS/rtACS induced improvements in visually guided performance that need to be confirmed in larger-sample trials. NCT01418820 (clinicaltrials.gov) |
| Databáze: | OpenAIRE |
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