A randomised comparison of a third-generation regimen (PACEBOM) with a standard regimen (CHOP) in patients with histologically aggressive non-Hodgkin's lymphoma: a British National Lymphoma Investigation report
| Autor: | Donald Milligan, P Hoskin, David C. Linch, G. Vaughan Hudson, Barry W. Hancock, L Anderson, B. Vaughan Hudson, P. A. Stevenson, Adrian C. Newland, K. A. MacLennan, David Cunningham, J. K. Wood, Walter M Gregory |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Vincristine medicine.medical_treatment Prednisolone CHOP Bleomycin Prednisone Internal medicine hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols medicine Humans Lymphoma Large-Cell Immunoblastic Cyclophosphamide Aged Etoposide Neoplasm Staging Chemotherapy business.industry Lymphoma Non-Hodgkin Middle Aged medicine.disease Survival Analysis Surgery Lymphoma Non-Hodgkin's lymphoma Regimen Methotrexate Oncology Doxorubicin Female Lymphoma Large B-Cell Diffuse business medicine.drug Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | A combination of cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) has been a standard therapy for histologically aggressive non-Hodgkin's lymphomas for over 20 years, but several newer regimens, referred to as second or third generation, have been reported to give improved results in single-centre studies. Positive evidence from randomised trials has been lacking, and the British National Lymphoma Investigation therefore commenced a randomised comparison of CHOP vs a third-generation regimen, PACEBOM, in November 1987. A total of 459 eligible patients were entered into the trial: 226 in the CHOP arm and 233 in the PACEBOM arm. Overall, there was no significant difference in outcome between the two arms of the trial. In patients with stage IV disease there was an apparent improvement in survival for those treated with PACEBOM, but considerable caution must be exercised with such subgroup analysis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|