RAD51: beyond the break
| Autor: | Fumiko Esashi, Isabel E. Wassing |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
genetic processes RAD51 Context (language use) Review Biology Genomic Instability Genomic Stability 03 medical and health sciences 0302 clinical medicine Humans Double-stranded DNA breaks DNA Breaks Double-Stranded Homologous recombination Double-Stranded DNA Breaks DNA replication Cell Biology Replicative stress DNA metabolism enzymes and coenzymes (carbohydrates) Fork protection 030104 developmental biology Evolutionary biology Dna breaks health occupations Rad51 Recombinase biological phenomena cell phenomena and immunity 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Seminars in Cell & Developmental Biology |
| DOI: | 10.1016/j.semcdb.2020.08.010 |
| Popis: | As the primary catalyst of homologous recombination (HR) in vertebrates, RAD51 has been extensively studied in the context of repair of double-stranded DNA breaks (DSBs). With recent advances in the understanding of RAD51 function extending beyond DSBs, the importance of RAD51 throughout DNA metabolism has become increasingly clear. Here we review the suggested roles of RAD51 beyond HR, specifically focusing on their interplay with DNA replication and the maintenance of genomic stability, in which RAD51 function emerges as a double-edged sword. |
| Databáze: | OpenAIRE |
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