Thrombosis of the deep cerebral veins with excessive bilateral infarction in a premature infant with the thrombogenic 4G/4G genotype of the plasminogen activator inhibitor-1
| Autor: | Karl Schneider, F. A. M. Baumeister, K. Auberger |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Pathology medicine.medical_specialty Deep vein Infarction Infant Premature Diseases chemistry.chemical_compound Plasminogen Activator Inhibitor 1 medicine Humans Promoter Regions Genetic Alleles business.industry Fontanelle Homozygote Infant Newborn Cerebral Infarction medicine.disease Thrombosis Venous thrombosis medicine.anatomical_structure chemistry Plasminogen activator inhibitor-1 Pediatrics Perinatology and Child Health Choroid plexus Intracranial Thrombosis Tomography X-Ray Computed business Plasminogen activator Infant Premature |
| Zdroj: | European Journal of Pediatrics. 159:239-242 |
| ISSN: | 1432-1076 0340-6199 |
| DOI: | 10.1007/s004310050062 |
| Popis: | We report on a preterm infant with deep cerebral venous thrombosis, a rare condition in this age group. This premature infant had a gestational age of 33 weeks and normal development until day 18, when he presented with tonic seizures and a tense fontanelle. Ultrasound and computed tomography revealed bilateral haemorrhagic infarction of the whole region drained by the deep cerebral veins, including the periventricular white matter, thalamus and choroid plexus. The child was homozygous for the 4G allele of the plasminogen activator inhibitor-1 (PAI-1) 4G/5G promoter polymorphism.In patients with bilateral cerebral infarction, thrombosis of the deep cerebral veins should be considered. In addition the role of prothrombotic risk factors, including PAI-1 4G/5G promoter polymorphism, in cerebral vein thrombosis should be clarified in a multicentre study. |
| Databáze: | OpenAIRE |
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