MicroRNA sequence analysis identifies microRNAs associated with peri-implantitis in dogs
| Autor: | Hui Huang, Xipeng Chen, Tingting Wu, Qinhua Gu, Wenxiang Mi, Xiaolin Wu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine MAPK/ERK pathway Sequence analysis Gingiva Biophysics Osteoclasts Inflammation Biology Bioinformatics Biochemistry miRNA sequence analysis 03 medical and health sciences Dogs 0302 clinical medicine Osteogenesis Osteoclast microRNA medicine Animals Bone Resorption Molecular Biology Gene Research Articles Dental Implants Mechanism (biology) 030206 dentistry Cell Biology Peri-Implantitis Stomatitis Denture Disease Models Animal MicroRNAs 030104 developmental biology medicine.anatomical_structure Mitogen-Activated Protein Kinases medicine.symptom Signal transduction Research Article |
| Zdroj: | Bioscience Reports |
| ISSN: | 1573-4935 0144-8463 |
| DOI: | 10.1042/bsr20170768 |
| Popis: | Peri-implantitis, which is characterized by dense inflammatory infiltrates and increased osteoclast activity, can lead to alveolar bone destruction and implantation failure. miRNAs participate in the regulation of various inflammatory diseases, such as periodontitis and osteoporosis. Therefore, the present study aimed to investigate the differential expression of miRNAs in canine peri-implantitis and to explore the functions of their target genes. An miRNA sequence analysis was used to identify differentially expressed miRNAs in peri-implantitis. Under the criteria of a fold-change >1.5 and P |
| Databáze: | OpenAIRE |
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