Pd-PEPPSI-IPent: an active, sterically demanding cross-coupling catalyst and its application in the synthesis of tetra-ortho-substituted biaryls

Autor:	Selçuk Çalimsiz, Michael G. Organ, Ka Hou Hoi, Alan J. Lough, Mahmoud Sayah
Rok vydání:	2009
Předmět:	Steric effects biology Aryl chemistry.chemical_element General Chemistry General Medicine biology.organism_classification Catalysis PEPPSI chemistry.chemical_compound chemistry Polymer chemistry Tetra Organic chemistry Carbene Palladium
Zdroj:	Angewandte Chemie (International ed. in English). 48(13)
ISSN:	1521-3773
Popis:	Incredible Bulk: A series of N-heterocyclic carbene catalysts (see picture) were prepared and evaluated in the Suzuki-Miyaura reaction. A variety of sterically encumbered tetra-ortho-substituted biaryl products were formed from unreactive aryl chlorides using the isopentyl-substituted catalyst at temperatures ranging from 65 degrees C to room temperature. The cyclopentyl-substituted catalyst was virtually inactive, demonstrating that "flexible bulk" is essential to promote these transformations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b7db247d3b8b6c95af6f3969210339 https://pubmed.ncbi.nlm.nih.gov/19226587 Zobrazit plný text záznamu Plný text