Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population
| Autor: | Matthias M. Mauschitz, Pieter W.M. Bonnemaijer, Kersten Diers, Franziska G. Rauscher, Tobias Elze, Christoph Engel, Markus Loeffler, Johanna Maria Colijn, M. Arfan Ikram, Johannes R. Vingerling, Katie M. Williams, Christopher J. Hammond, Catherine Creuzot-Garcher, Alain M. Bron, Rufino Silva, Sandrina Nunes, Cécile Delcourt, Audrey Cougnard-Grégoire, Frank G. Holz, Caroline C.W. Klaver, Monique M.B. Breteler, Robert P. Finger, Niyazi Acar, Eleftherios Anastosopoulos, Augusto Azuara-Blanco, Tos Berendschot, Arthur Bergen, Geir Bertelsen, Christine Binquet, Alan Bird, Martin Bobak, Morten Bøgelund Larsen, Camiel Boon, Rupert Bourne, Lionel Brétillon, Rebecca Broe, Alain Bron, Gabrielle Buitendijk, Maria Luz Cachulo, Vittorio Capuano, Isabelle Carrière, Usha Chakravarthy, Michelle Chan, Petrus Chang, Johanna Colijn, Angela Cree, Phillippa Cumberland, José Cunha-Vaz, Vincent Daien, Eiko De Jong, Gabor Deak, Marie-Noëlle Delyfer, Anneke den Hollander, Martha Dietzel, Maja Gran Erke, Pedro Faria, Claudia Farinha, Sascha Fauser, Robert Finger, Astrid Fletcher, Paul Foster, Panayiota Founti, Theo Gorgels, Jakob Grauslund, Franz Grus, Christopher Hammond, Hans-Werner Hense, Manuel Hermann, René Hoehn, Ruth Hogg, Frank Holz, Carel Hoyng, Nomdo Jansonius, Sarah Janssen, Eveline Kersten, Anthony Khawaja, Caroline Klaver, Jean-François Korobelnik, Julia Lamparter, Mélanie Le Goff, Yara Lechanteur, Terho Lehtimäki, Irene Leung, Andrew Lotery, Matthias Mauschitz, Magda Meester, Bénédicte Merle, Verena Meyer zu Westrup, Edoardo Midena, Stefania Miotto, Alireza Mirshahi, Sadek Mohan-Saïd, Michael Mueller, Alyson Muldrew, Joaquim Murta, Stefan Nickels, Christopher Owen, Tunde Peto, Norbert Pfeiffer, Stefano Piermarocchi, Elena Prokofyeva, Jugnoo Rahi, Olli Raitakari, Franziska Rauscher, Luisa Ribeiro, Marie-Bénédicte Rougier, Alicja Rudnicka, José Sahel, Aggeliki Salonikiou, Clarisa Sanchez, Steffen Schmitz-Valckenberg, Alexander Schuster, Cédric Schweitzer, Tatiana Segato, Jasmin Shehata, Giuliana Silvestri, Christian Simader, Eric Souied, Martynas Speckauskas, Henriet Springelkamp, Robyn Tapp, Fotis Topouzis, Elisa van Leeuwen, Virginie Verhoeven, Timo Verzijden, Therese Von Hanno, Peter Wiedemann, Katie Williams, Christian Wolfram, Jennifer Yip, Jennyfer Zerbib |
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| Přispěvatelé: | OEil, nutrition et signalisation cellulaire [CSGA], Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Service d'Ophtalmologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neuropsychiatrie : recherche épidémiologique et clinique, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Montrachet Study: Funding was provided by an Inter-regional grant (PHRC) and the Regional Council of Burgundy. Funded by INRA, CNRS, Université de Bourgogne, Regional Council of Burgundy France (PARI Agrale 1), FEDER (European Funding for Regional Economic Development), and French Government grant managed by the French National Research Agency (ANR) as part of the 'Investissements d’Avenir' program (reference ANR-11-LABX-0021-01-LipSTIC Labex)., Human Genetics, ANS - Cellular & Molecular Mechanisms, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: MHeNs - R3 - Neuroscience, Oogheelkunde, MUMC+: MA UECM Oogartsen MUMC (9), Perceptual and Cognitive Neuroscience (PCN), Epidemiology, Ophthalmology |
| Rok vydání: | 2018 |
| Předmět: |
Retinal Ganglion Cells
Cross-Sectional Studies Disease Progression Europe Glaucoma Humans Intraocular Pressure Nerve Fibers Optic Disk Population Surveillance Tomography Optical Coherence methods [Tomography Optical Coherence] Intraocular pressure OPTICAL COHERENCE TOMOGRAPHY Cross-sectional study Nerve Fibers/pathology ANYANG CHILDHOOD EYE AXIAL LENGTH Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] INTRAOCULAR-PRESSURE Tomography Optical Coherence/methods Rotterdam Study 0302 clinical medicine physiopathology [Glaucoma] GLAUCOMA epidemiology [Glaucoma] Tomography education.field_of_study GANGLION-CELL LAYER epidemiology [Europe] pathology [Nerve Fibers] ASSOCIATION 3. Good health ALZHEIMERS-DISEASE Population Surveillance/methods pathology [Optic Disk] methods [Population Surveillance] Optic Disk/pathology Cohort study Glaucoma/diagnosis medicine.medical_specialty Population physiology [Intraocular Pressure] Retinal Ganglion Cells/pathology pathology [Retinal Ganglion Cells] Europe/epidemiology 03 medical and health sciences Ophthalmology medicine ddc:610 Intraocular Pressure/physiology education business.industry diagnosis [Glaucoma] CONSORTIUM medicine.disease Confidence interval ta3125 Optical Coherence 030221 ophthalmology & optometry DISC SIZE business Body mass index 030217 neurology & neurosurgery [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Ophthalmology, 125, 1526-1536 Ophthalmology: Journal of The American Academy of Ophthalmology Ophthalmology: Journal of The American Academy of Ophthalmology, Elsevier, 2018, 125 (10), pp.1526-1536. ⟨10.1016/j.ophtha.2018.03.026⟩ Mauschitz, M M, Bonnemaijer, P W M, Diers, K, Rauscher, F G, Elze, T, Engel, C, Loeffler, M, Colijn, J M, Ikram, M A, Vingerling, J R, Williams, K M, Hammond, C J, Creuzot-Garcher, C, Bron, A M, Silva, R, Nunes, S, Delcourt, C, Cougnard-Grégoire, A, Holz, F G, Klaver, C C W, Breteler, M M B, Finger, R P & European Eye Epidemiology (E3) Consortium 2018, ' Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population ', Ophthalmology, vol. 125, no. 10, pp. 1526–1536 . https://doi.org/10.1016/j.ophtha.2018.03.026 Ophthalmology, 125(10), 1526-1536. Elsevier Inc. Ophthalmology, 125(10), 1526-1536. Elsevier Science Ophthalmology 125(10), 1526-1536 (2018). doi:10.1016/j.ophtha.2018.03.026 Ophthalmology, 125, 10, pp. 1526-1536 Ophthalmology, 125(10), 1526-1536. ELSEVIER SCIENCE INC Mauschitz, M M, Bonnemaijer, P W M, Diers, K, Rauscher, F G, Elze, T, Engel, C, Loeffler, M, Colijn, J M, Ikram, M A, Vingerling, J R, Williams, K M, Hammond, C J, Creuzot-Garcher, C, Bron, A M, Silva, R, Nunes, S, Delcourt, C, Cougnard-Grégoire, A, Holz, F, Klaver, C & Breteler, M M B & Finger, R P 2018, ' Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population ', Ophthalmology . https://doi.org/10.1016/j.ophtha.2018.03.026 |
| ISSN: | 0161-6420 |
| Popis: | Purpose: To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population.Design: Cross-sectional meta-analysis.Participants: A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9 +/- 12.3-82.1 +/- 4.2 years) of the European Eye Epidemiology (E3) consortium.Methods: We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis.Main Outcome Measures: Determinants of pRNFLT.Results: Mean pRNFLT ranged from 86.8 +/- 21.4 mu m in the Rotterdam Study I to 104.7 +/- 12.5 mu m in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (beta = -0.38 mu m/year; 95% confidence interval [CI], -0.57 to -0.18), higher intraocular pressure (10P) (beta = -0.36 mu m/mmHg; 95% CI, -0.56 to -0.15), visual impairment (beta = -5.50 mu m; 95% CI, -9.37 to -1.64), and history of systemic hypertension (beta = -0.54 mu m; 95% CI, -1.01 to -0.07) and stroke (beta = -1.94 mu m; 95% CI, -3.17 to -0.72). A suggestive, albeit nonsignificant, association was observed for dementia (beta = -3.11 mu m; 95% CI, -6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (beta = 1.39 mu m/diopter; 95% CI, 1.19-1.59) and smoking (beta = 1.53 mu m; 95% CI, 1.00-2.06 for current smokers compared with never-smokers).Conclusions: In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities. (C) 2018 by the American Academy of Ophthalmology |
| Databáze: | OpenAIRE |
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