The Spatial Distribution of Actin and Mechanical Cycle of Myosin Are Different in Right and Left Ventricles of Healthy Mouse Hearts
| Autor: | Rafal Fudala, Julian Borejdo, Janhavi Nagwekar, Zygmunt Gryczynski, Sangram Raut, Ryan Rich, Ignacy Gryczynski, Divya Duggal |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Models
Molecular Contraction (grammar) Heart Ventricles Myosins Biology Biochemistry Article Mice 03 medical and health sciences Dogs 0302 clinical medicine Myofibrils medicine.artery Myosin medicine Animals Ventricular Function Tissue Distribution 030304 developmental biology 0303 health sciences Aorta Molecular Motor Proteins Models Cardiovascular Dilated cardiomyopathy Anatomy medicine.disease Myocardial Contraction Actins Mice Inbred C57BL Kinetics medicine.anatomical_structure Ventricle Heart failure Pulmonary artery Female Myofibril 030217 neurology & neurosurgery |
| Zdroj: | Biochemistry |
| ISSN: | 1520-4995 0006-2960 |
| Popis: | The contraction of the right ventricle (RV) expels blood into the pulmonary circulation, and the contraction of the left ventricle (LV) pumps blood into the systemic circulation through the aorta. The respective afterloads imposed on the LV and RV by aortic and pulmonary artery pressures create very different mechanical requirements for the two ventricles. Indeed, differences have been observed in the contractile performance between left and right ventricular myocytes in dilated cardiomyopathy, in congestive heart failure, and in energy usage and speed of contraction at light loads in healthy hearts. In spite of these functional differences, it is commonly believed that the right and left ventricular muscles are identical because there were no differences in stress development, twitch duration, work performance, or power among the RV and LV in dogs. This report shows that on a mesoscopic scale [when only a few molecules are studied (here three to six molecules of actin) in ex vivo ventricular myofibrils], the two ventricles in rigor differ in the degree of orientational disorder of actin within in filaments and during contraction in the kinetics of the cross-bridge cycle. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|