Epidemiology of Respiratory Pathogens Among Children Hospitalized for Pneumonia in Xiamen: A Retrospective Study
| Autor: | Xin-Yi Zheng, Xiao-Man Zhou, Haixia Zhang, Xin-Zhu Lin, Yong-Peng Sun, Yulin Zhou, Jun Zhang, Zizheng Zheng, Yingying Su |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Klebsiella pneumoniae Respiratory pathogens 030106 microbiology medicine.disease_cause Haemophilus influenzae Moraxella catarrhalis 03 medical and health sciences 0302 clinical medicine Internal medicine Streptococcus pneumoniae medicine Xiamen 030212 general & internal medicine Children Original Research biology business.industry Pneumonia medicine.disease biology.organism_classification respiratory tract diseases Vaccination Infectious Diseases Staphylococcus aureus Respiratory virus business |
| Zdroj: | Infectious Diseases and Therapy |
| ISSN: | 2193-6382 2193-8229 |
| Popis: | Objectives To investigate the etiology of common respiratory pathogens in children < 2 years of age hospitalized with pneumonia in Xiamen from 2014 to 2017. Methods The medical records of 5581 children with pneumonia were retrospectively reviewed. Direct immunofluorescent test was used for respiratory virus testing. Bacteria were detected by conventional culture method. The results of pathogen detection at admission were analyzed as well as the clinical outcomes of children. Results The burden of hospitalized children with pneumonia was highest among infants < 6 months old (58.2%). Respiratory syncytial virus (RSV) was the most common respiratory virus (26.0%) followed by parainfluenza (4.8%) and adenovirus (3.2%). Haemophilus influenzae was the most common bacteria detected (16.6%) followed by Moraxella catarrhalis (13.4%), Staphylococcus aureus (13.0%), Streptococcus pneumoniae (12.3%), Escherichia coli (5.1%) and Klebsiella pneumoniae (4.8%). Notably, RSV and K. pneumoniae were detected more frequently in severe pneumonia (35.0% and 10.9%) versus mild pneumonia (25.6% and 4.6%), with higher rates of ICU admissions, longer hospital stays and higher hospital costs compared to those infected with other respiratory pathogens. Conclusions Among children < 2 years of age hospitalized with pneumonia in Xiamen, RSV was the most common respiratory virus, while H. influenzae and S. pneumoniae remained the predominant bacterial pathogens detected. Considering the low implementation rate of vaccines against pneumococcal and Hib pneumonia in China, there is an urgent need to increase both vaccination rates to reduce pneumococcal and Hib disease burden. |
| Databáze: | OpenAIRE |
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