Risk factors of lymphovascular invasion in hypopharyngeal squamous cell carcinoma and its influence on prognosis
| Autor: | Gao Gang, Dong Pin, Chen LiXiao, Zhang Cheng, Zhang Yu, Chen Xinwei |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Multivariate analysis Lymphovascular invasion Logistic regression 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Neoplasm Invasiveness Risk factor Stage (cooking) 030223 otorhinolaryngology Survival rate Neoplasm Staging Retrospective Studies Squamous Cell Carcinoma of Head and Neck business.industry Proportional hazards model General Medicine Prognosis Exact test Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis business |
| Zdroj: | European Archives of Oto-Rhino-Laryngology. 279:1473-1479 |
| ISSN: | 1434-4726 0937-4477 |
| Popis: | Lymphatic vascular invasion (LVI) is a poor prognostic factor for hypopharyngeal squamous cell carcinoma (HPSCC), but the risk factors of LVI and its relationship with clinicopathological of HPSCC remain unclear. This study aims to explore these issues. We retrospectively analyzed the clinicopathological data of 170 patients with HPSCC from January 2011 to December 2015. The relationship between LVI and clinicopathologic was analyzed by Chi-square test or Fisher’s exact test. The risk factors of LVI were examined using a logistic regression model, while risk factors of survival rate were carried out using the Cox regression model. LVI occurred in 59 cases (34.7%). In multivariate analysis, T3–4 stage (HR = 2.877; 95% CI: 1.379–6.004; p = 0.005), N2–3 stage (HR = 2.325; 95% CI: 1.120–4.824; p = 0.024), and poor differentiation (HR = 2.983; 95% CI: 1.229–7.242; p = 0.016) were independent risk factors for LVI; positive LVI was an independent risk factor for local recurrence (HR = 2.488; 95% CI: 1.150–5.383; p = 0.021), poor 5-year OS (HR = 0.375; 95% CI: 0.232–0.606; p |
| Databáze: | OpenAIRE |
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