Promoting effect of 2,4-diaminoanisole sulfate on rat thyroid carcinogenesis
| Autor: | Noboru Konishi, Hiroyuki Hashimoto, Witaya Thamavit, Matsuki H, Yoshiteru Kitahori, Masato Ohshima, Yoshio Hiasa, Shigenori Minami |
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| Rok vydání: | 1989 |
| Předmět: |
Adenoma
Male Cancer Research medicine.medical_specialty Hair Dyes Hair Preparations Thyroid Gland Thyrotropin Phenylenediamines chemistry.chemical_compound Thyroid-stimulating hormone Internal medicine Follicular phase medicine Animals Thyroid Neoplasms Goitrogen Triiodothyronine Cocarcinogenesis Hyperplasia business.industry Thyroid Body Weight Carcinoma Rats Inbred Strains Organ Size Rats Thyroxine Endocrinology medicine.anatomical_structure Oncology chemistry Nitrosamine Toxicity Carcinogens Thyroid function business |
| Zdroj: | Cancer letters. 45(2) |
| ISSN: | 0304-3835 |
| Popis: | Two experiments were conducted to examine the effects of 2,4-diaminoanisole sulfate (2,4-DAAS) on thyroid function and carcinogenesis in male Wistar rats. In experiment 1, feeding with 2,4-DAAS resulted in significantly elevated levels of thyroid stimulating hormone (TSH), reduced thyroxine (T4) and triiodothyronine (T3) in the serum, although the latter had almost recovered to normal levels by week 6. However, skin application did not affect serum levels. In experiment 2, administration of 0.5% 2,4-DAAS in the diet for 19 weeks, a week after a single 210 mg 100 g body weight i.p. injection of N-bis(2-hydroxypropyl)nitrosamine (DHPN), significantly increased the incidence and numbers of preneoplastic lesions (focal hyperplasia), adenomas and carcinomas developing in the thyroid gland. Histologically, brown pigment was usually observed within follicular epithelial cells in non-tumorous regions, but not in the tumors themselves. |
| Databáze: | OpenAIRE |
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