RANTES Augments Radical Oxygen Products from Eosinophils
| Autor: | Nobana Hayashi, Shigenori Nakajima, Tomokazu Kakazu, Takahiro Yamamoto, Dai Kurachi, Junichi Chihara |
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| Rok vydání: | 1994 |
| Předmět: |
Chemokine
Free Radicals medicine.medical_treatment Immunology Inflammation Allergic inflammation Superoxides Eosinophil activation medicine Humans Immunology and Allergy Chemokine CCL5 Lymphokines biology Hydroxyl Radical Chemistry Chemotaxis General Medicine respiratory system Eosinophil Eosinophils Oxygen medicine.anatomical_structure Cytokine biology.protein medicine.symptom Platelet factor 4 |
| Zdroj: | International Archives of Allergy and Immunology. 104:52-53 |
| ISSN: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000236752 |
| Popis: | RANTES, which is released from thrombin-stimulated platelets, is a member of the 8-kD cytokine family that has been shown to possess chemotactic activity for eosinophils. Thus, in this study, we examined the effect of RANTES on radical oxygen products from eosinophils. RANTES treatment resulted in the enhancement of peak value and intergrated value of productivity of eosinophil-mediated radical oxygen products determined by luminol-dependent chemiluminescence of EoL-3 cells stimulated with A23187. In addition, the radical oxygen products of EoL-1 or eosinophils showed similar results. Thus, we could conclude that platelets might play an important role in the pathogenesis of allergic inflammation through the involvement in the selective eosinophil infiltration and eosinophil activation by releasing RANTES. |
| Databáze: | OpenAIRE |
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