Characterizing the Neuroprotective Effects of S/B Remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) in Spinal Cord Injury
Autor: | Wen Cheng Huang, Ching Jung Chen, Di You Lin, Ming Chao Huang, Henrich Cheng, Hsin Chun Yang, May Jywan Tsai, Dann Ying Liou, Tsung Hsi Tu |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Pharmaceutical Science
Stimulation Hindlimb Pharmacology Neuroprotection Analytical Chemistry Sho-Saiko-To lcsh:QD241-441 03 medical and health sciences 0302 clinical medicine lcsh:Organic chemistry Drug Discovery medicine Physical and Theoretical Chemistry Spinal cord injury 030304 developmental biology 0303 health sciences biology business.industry Organic Chemistry biology.organism_classification Spinal cord medicine.disease neuronal/glial cultures anti-inflammation spinal cord injury medicine.anatomical_structure Chemistry (miscellaneous) Toxicity Molecular Medicine Scutellaria baicalensis neuroprotection Neuron business herbal remedy 030217 neurology & neurosurgery |
Zdroj: | Molecules, Vol 24, Iss 10, p 1885 (2019) Molecules Volume 24 Issue 10 |
ISSN: | 1420-3049 |
Popis: | The main causes of dysfunction after a spinal cord injury (SCI) include primary and secondary injuries that occur during the first minutes, hours, to days after injury. This treatable secondary cascade provides a window of opportunity for delivering therapeutic interventions. An S/B remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) has anti-inflammatory, cytoprotective, and anticarcinogenic effects in liver or neurodegenerative diseases. The present work examined the effect of S/B on injured spinal cord neurons in cultures and in vivo. S/B effectively reduced peroxide toxicity and lipopolysaccharide stimulation in both spinal cord neuron/glial and microglial cultures with the involvement of PKC and HSP70. The effect of S/B was further conducted in contusive SCI rats. Intraperitoneal injections of S/B to SCI rats preserved spinal cord tissues and effectively attenuated microglial activation. Consistently, S/B treatment significantly improved hindlimb functions of SCI rats. In the acute stage of injury, S/B treatment markedly reduced the levels of ED1 expression and lactate and had a tendency to decrease lipid peroxidation. Taken together, we demonstrated long-term hindlimb restoration alongside histological improvements with systemic S/B remedy treatment in a clinically relevant model of contusive SCI. Our findings highlight the potential of an S/B remedy for acute therapeutic intervention after SCI. |
Databáze: | OpenAIRE |
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