Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma

Autor:	Shu Ting Huang, Xi Zhao Li, Rong Xin Liang, Sen wei Jiang, Lan Zhang, Yu Chuan Jiang, Min Zheng, Jian Hua Wang, Pei Fen Zhang, Xing Juan Yu, Zhe Sheng Wen, Zi Gang Liu, Yi Nan Jiang
Rok vydání:	2019
Předmět:	Adult Male 0301 basic medicine Cancer Research Gene Expression CD47 Antigen Positive correlation Esophageal squamous cell carcinoma 03 medical and health sciences 0302 clinical medicine Immune system Cancer stem cell Biomarkers Tumor Humans Medicine Radiology Nuclear Medicine and imaging CD133 AC133 Antigen CD47 neoplasms Survival analysis Original Research Aged Neoplasm Staging Proportional hazards model business.industry ESCC Middle Aged Prognosis Immunohistochemistry Survival Analysis therapeutic 030104 developmental biology Oncology 030220 oncology & carcinogenesis Neoplastic Stem Cells Cancer research CSCs Female Esophageal Squamous Cell Carcinoma Neoplasm Grading business Cancer Prevention
Zdroj:	Cancer Medicine
ISSN:	2045-7634
Popis:	Background Treatments based on the inhibition of pivotal signals of cancer stem cells (CSCs) are on a promising track. Recent studies have shown that targeting CSCs with broader immune‐based therapeutic methods, for example, the anti‐CD47 treatment, may serve as a more potent strategy for eliminating these intractable cells. We aimed to explore the prognostic effects of CD47/CD133 and the potential therapeutic significance of CD47 in esophageal squamous cell carcinoma (ESCC). Methods Immunohistochemistry was employed to identify the characteristics of CD47 and CD133 in 26 pairs of tumor tissues and adjacent non‐tumor tissues and 136 ESCC tissues. Kaplan‐Meier analysis and Cox proportional hazards models were built for estimating the prognostic values of CD47 and CD133 expression and their combined stemness index. Sphere formation assays were undertaken to explore the effects of CD47 inhibition on primary human ESCC CSCs. Results Results conclude that CD47 and CD133 expression is increased in tumor tissues as compared to adjacent non‐tumor tissues. A positive correlation between CD47/CD133 expression and differentiation was found in 136 ESCC patients. Survival analysis indicated that patients with high CD47 or CD133 expression exhibited poor overall survival and progression‐free survival (PFS). The combination of high CD47 and CD133 expression was a reliable independent prognostic factor for both OS (HR = 1.940, 95% CI = 1.399‐2.690, P
Databáze:	OpenAIRE
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