Targeting Transforming Growth Factor-β Signaling in Primary Open-Angle Glaucoma
| Autor: | Scott M. Wentz, Ambika B. Rao, Josh C. Gross, Alon Harris, Jenny Wang, Brent Siesky, Nathaniel J. Kim, Mark A. Prendes, Loor Alshawa, Alexander Synder |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Intraocular pressure Cell signaling genetic structures Open angle glaucoma Optic Disk Glaucoma Aqueous Humor 03 medical and health sciences 0302 clinical medicine Trabecular Meshwork Transforming Growth Factor beta medicine Humans Molecular Targeted Therapy Antihypertensive Agents Intraocular Pressure Clinical Trials as Topic business.industry medicine.disease eye diseases Extracellular Matrix Surgery Cell biology Ophthalmology 030104 developmental biology medicine.anatomical_structure Retinal ganglion cell Astrocytes 030221 ophthalmology & optometry Optic nerve sense organs Trabecular meshwork business Glaucoma Open-Angle Signal Transduction Transforming growth factor |
| Zdroj: | Journal of Glaucoma. 26:390-395 |
| ISSN: | 1057-0829 |
| Popis: | Transforming growth factor-β (TGF-β) may play a role in the pathogenesis of primary open-angle glaucoma (POAG). Elevated levels of TGF-β are found in the aqueous humor and in reactive optic nerve astrocytes in patients with glaucoma. In POAG, aqueous humor outflow resistance at the trabecular meshwork (TM) leads to increased intraocular pressure and retinal ganglion cell death. It is hypothesized that TGF-β increases outflow resistance by altering extracellular matrix homeostasis and cell contractility in the TM through interactions with other proteins and signaling molecules. TGF-β may also be involved in damage to the optic nerve head. Current available therapies for POAG focus exclusively on lowering intraocular pressure without addressing extracellular matrix homeostasis processes in the TM. The purpose of this review is to discuss possible therapeutic strategies targeting TGF-β in the treatment of POAG. Herein, we describe the current understanding of the role of TGF-β in POAG pathophysiology, and examine ways TGF-β may be targeted at the levels of production, activation, downstream signaling, and homeostatic regulation. |
| Databáze: | OpenAIRE |
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