Effect of phosphate binders on supplemental iron absorption in healthy subjects
| Autor: | Stacy Hoshaw-Woodard, Maria C. Pruchnicki, William H. Bay, James D. Coyle |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Adolescent medicine.drug_class Iron Inorganic chemistry chemistry.chemical_element Administration Oral Biological Availability Sevelamer Calcium Acetates Calcium Carbonate Phosphates chemistry.chemical_compound medicine Polyamines Humans Pharmacology (medical) Drug Interactions Pharmacology Cross-Over Studies Chemistry Calcium Compounds Phosphate Crossover study Bioavailability Phosphate binder Calcium carbonate Intestinal Absorption Epoxy Compounds Female Polyethylenes Nuclear chemistry medicine.drug |
| Zdroj: | Journal of clinical pharmacology. 42(10) |
| ISSN: | 0091-2700 |
| Popis: | A single-dose, prospective, randomized, four-treatment, four-period crossover study was conducted to determine the acute effect of therapeutically equivalent doses of three commonly used phosphate binders on oral iron absorption. Twenty-three healthy subjects received 65 mg of elemental iron alone and with each phosphate binder (calcium carbonate 3000 mg, calcium acetate 2668 mg, or sevelamer HCl 2821 mg). Area under the change in plasma iron concentration-time curve over 6 hours postdosing was measured. ANOVA was used to assess the statistical significance of differences in iron absorption among the treatments. The relative bioavailability of iron administered with each phosphate binder compared to iron administered alone was estimated. The relative iron bioavailabilities (95% confidence intervals) for the calcium carbonate, calcium acetate, and sevelamer HCI treatments were 0.81 (0.70, 0.94), 0.73 (0.63, 0.85), and 0.90 (0.78, 1.05), respectively. Thus, single doses of both calcium-based phosphate binders significantly reduced single-dose iron absorption, while sevelamer HCl did not. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text