Intercellular adhesion molecule-1 (ICAM-1) expression by lymph node dendritic cells: comparison with epidermal Langerhans cells
| Autor: | Ian Kimber, Marie Cumberbatch, S W Peters, Sarah J. Gould |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pathology
medicine.medical_specialty Langerhans cell Immunology Intercellular Adhesion Molecule-1 Biology Mice Lymph node stromal cell medicine Animals Immunology and Allergy Antigen-presenting cell Lymph node Mice Inbred BALB C Cell adhesion molecule Antibodies Monoclonal Cell Differentiation Dendritic Cells Dendritic cell Flow Cytometry Immunohistochemistry Molecular biology medicine.anatomical_structure Langerhans Cells Lymph Nodes Lymph Cell Adhesion Molecules |
| Zdroj: | Immunology Letters. 32:105-110 |
| ISSN: | 0165-2478 |
| DOI: | 10.1016/0165-2478(92)90101-s |
| Popis: | Following skin sensitization of mice, epidermal Langerhans cells (LC) are stimulated to migrate via the afferent lymphatics to the draining lymph nodes. Previous studies have demonstrated that, while in transit, LC acquire the characteristics of mature dendritic cells (DC) and develop into potent immunostimulatory cells. In the present study the expression by LC and lymph node DC of intercellular adhesion molecule-1 (ICAM-1) has been compared. Freshly-isolated LC expressed only very low levels of ICAM-1. In contrast lymph node DC, irrespective of whether they were isolated from resting lymph nodes or from activated lymph nodes draining the site of sensitization with oxazolone, exhibited significant membrane ICAM-1. As a substantial proportion of the DC found within the draining nodes of skin sensitized mice derive from epidermal LC it is apparent that, during migration from the skin, LC are induced to express increased ICAM-1. Such is compatible with the development of LC into effective antigen presenting cells. |
| Databáze: | OpenAIRE |
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