Genome Characterization of Yellow Fever Virus Wild-Type Strain Asibi, Parent to Live-Attenuated 17D Vaccine, from Three Different Sources
| Autor: | Alan D.T. Barrett, Emily H. Davis, Steven G. Widen, Jill K. Thompson |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
viruses 030106 microbiology Genome Viral Biology Vaccines Attenuated Asibi Microbiology Genome Virus yellow fever 03 medical and health sciences Viral Envelope Proteins Virus vaccine Serial passage Virology 17D vaccine medicine wild-type virus Antigens Viral Whole Genome Sequencing Brief Report Strain (biology) Yellow Fever Vaccine Yellow fever Genetic Variation Vaccine virus sequencing medicine.disease QR1-502 030104 developmental biology Infectious Diseases consensus compare Yellow fever virus Wild type strain |
| Zdroj: | Viruses, Vol 13, Iss 1383, p 1383 (2021) Viruses |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v13071383 |
| Popis: | The yellow fever virus vaccine, 17D, was derived through the serial passage of the wild-type (WT) strain Asibi virus in mouse and chicken tissue. Since its derivation, the mechanism of attenuation of 17D virus has been investigated using three 17D substrains and WT Asibi virus. Although all three substrains of 17D have been sequenced, only one isolate of Asibi has been examined genetically and all interpretation of attenuation is based on this one isolate. Here, we sequenced the genome of Asibi virus from three different laboratories and show that the WT strain is genetically homogenous at the amino acids that distinguish Asibi from 17D vaccine virus. |
| Databáze: | OpenAIRE |
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