Archeal Di-O-geranylgeranyl Glyceryl Phosphate Synthase of a UbiA Superfamily Member Provides Insight into the Multiple Human Diseases
| Autor: | Debjyoti Boral, Vamkudoth Koteswara Rao, Sureshkumar Ramasamy |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Membrane lipids
Archaeal Proteins Glyceryl Ethers Biochemistry Cell membrane 03 medical and health sciences chemistry.chemical_compound Membrane Lipids 0302 clinical medicine Structural Biology medicine Humans Archaeol 030304 developmental biology chemistry.chemical_classification 0303 health sciences Alkyl and Aryl Transferases biology ATP synthase Active site General Medicine Archaea medicine.anatomical_structure Enzyme Caldarchaeol chemistry Membrane protein Cardiovascular Diseases biology.protein 030217 neurology & neurosurgery |
| Zdroj: | Protein and peptide letters. 27(7) |
| ISSN: | 1875-5305 |
| Popis: | One of the unique characteristic features of the domain archaea, are the lipids that form the hydrophobic core of their cell membrane. These membrane lipids are characterized by distinctive isoprenoid biochemistry and the building blocks are two core lipid structures, sn-2,3- diphytanyl glycerol diether (archaeol) and sn-2,3-dibiphytanyl diglycerol tetraether (caldarchaeol). Archaeol has two phytanyl chains (C20) in a bilayer structure connected to the glycerol moiety by an ether bond. The enzyme involved in this bilayer formation is Di-O-Geranylgeranyl Glyceryl Phosphate Synthase (DGGGPS), which is a member of a very versatile superfamily of enzymes known as UbiA superfamily. Multiple sequence analysis of the typical members of the UbiA superfamily indicates that the majority of conserved residues are located around the central cavity of these enzymes. Interestingly few of these conserved residues in the human homologs are centrally implicated in several human diseases, on basis of the major mutations reported against these diseases in the earlier clinical studies. It remains to be investigated about the role of these conserved residues in the biochemistry of these enzymes. The binding and active site of these enzymes found to be similar architecture but have different substrate affinities ranging from aromatic to linear compounds. So further investigation of UbiA superfamily may be translated to novel therapeutic and diagnostic application of these proteins in human disease management. |
| Databáze: | OpenAIRE |
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