Evaluation of cinacalcet HCl treatment after kidney transplantation
| Autor: | O. Wang, Stewart A. Turner, Stuart M. Sprague, J.B. Copley, Michael J. Germain, S. Katznelson, T. Shah, O. Pankewycz, L. Stern |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Cinacalcet Calcimimetic Urology Parathyroid hormone Renal function Naphthalenes Bone and Bones Postoperative Complications Internal medicine medicine Humans Kidney transplantation Retrospective Studies Transplantation Hyperparathyroidism Kidney business.industry Patient Selection medicine.disease Kidney Transplantation Endocrinology medicine.anatomical_structure Parathyroid Hormone Hypercalcemia Surgery Hyperparathyroidism Secondary business Kidney disease medicine.drug Glomerular Filtration Rate |
| Zdroj: | Transplantation proceedings. 42(7) |
| ISSN: | 1873-2623 |
| Popis: | Hyperparathyroidism often remains or develops after kidney transplantation. Vitamin D sterol used as treatment for an elevated parathyroid hormone (PTH) level and associated bone disease may be contraindicated due to hypercalcemia. The calcimimetic cinacalcet HCl (cinacalcet), which lowers PTH and calcium (Ca) in chronic kidney disease patients, may represent an alternate therapeutic modality.This multicenter, retrospective, observational study examined 41 kidney transplant patients receiving cinacalcet for ≥3 months starting ≥3 months posttransplantation. Levels of intact PTH, Ca, and phosphorus (P) were examined during the assessment phase (3-6 months after initiation).Median PTH decreased 21.8% during the assessment phase (P.001), with 32.5% of patients exhibiting a ≥30% decrease in PTH from baseline. Median Ca decreased 6.8% (P.0001). Median serum P rose 10.0% (P = .0124), but remained within normal limits. The estimated glomerular filtration rate was stable throughout the study.Cinacalcet may be useful for the treatment of hyperparathyroidism after kidney transplantation. Randomized, prospectively designed clinical trials are required to confirm these results. |
| Databáze: | OpenAIRE |
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