Dopamine Prevents Ultraviolet B–induced Development and Progression of Premalignant Cutaneous Lesions through its D2 Receptors
| Autor: | Rita Mitra, Tatiana M. Oberyszyn, Xiaokui Mo, Madhavi Bhat, Sara B. Peters, Kai Lu, Sujit Basu, Partha Sarathi Dasgupta |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Agonist Cancer Research Ultraviolet Rays medicine.drug_class Dopamine Primary Cell Culture Cell Stimulation Article Pathogenesis Mice 03 medical and health sciences 0302 clinical medicine In vivo Dopamine receptor D2 medicine Carcinoma Animals Humans Cells Cultured Skin Receptors Dopamine D2 business.industry Endothelial Cells medicine.disease Keratosis Actinic Disease Models Animal 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Dopamine Agonists Disease Progression Cancer research Dopamine Antagonists business medicine.drug |
| Zdroj: | Cancer Prev Res (Phila) |
| ISSN: | 1940-6215 1940-6207 |
| Popis: | Although the role of dopamine (DA) in malignant tumors has been reported, its function in premalignant lesions is unknown. Herein we report that the stimulation of DA D2 receptors in endothelial cells in ultraviolet B (UVB)-induced cutaneous lesions in mice significantly reduced the tumor number, tumor burden, and malignant squamous cell carcinoma in these animals. DA D2 receptor agonist inhibited VEGFA-dependent proangiogenic genes in vitro and in vivo. However, the mice pretreated with selective DA D2 receptor antagonist inhibited the actions of the agonist, thereby suggesting that the action of DA was through its D2 receptors in the endothelial cells. To our knowledge, this study is the first to report DA-mediated regulation of pathogenesis and progression of UVB-induced premalignant skin lesions. Prevention Relevance: This investigation demonstrates the role of dopamine and its D2 receptors in UVB induced premalignant squamous cell skin lesions and how DA through its D2 receptors inhibits the development and progression of these lesions and subsequently prevents squamous cell carcinoma of the skin. |
| Databáze: | OpenAIRE |
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