New insights to the MLL recombinome of acute leukemias
| Autor: | Aline Renneville, Anja Möricke, Larisa Fechina, Martin Krzywinski, M. De Braekeleer, Eric Delabesse, Theodor Dingermann, L Lo Nigro, Shai Izraeli, Thomas Burmeister, Christian Meyer, Hélène Cavé, Jan Trka, R. Ben Abdelali, Julia Hofmann, Brian V. Balgobind, Mara Molkentin, U zur Stadt, G te Kronnie, L. Trakhtenbrot, Tomasz Szczepański, M. P. de Oliveira, D. Ilencikova, Sabine Strehl, Elizabeth Macintyre, Emmanuelle Clappier, E De Braekeleer, Beat W. Schäfer, Rolf Marschalek, Renate Panzer-Grümayer, Eric Kowarz, Eigil Kjeldsen, Jan Zuna, Cristina N. Alonso, Bernd Gruhn, M M van den Heuvel-Eibrink, Andrea Teigler-Schlegel, Li Chong Chan, J J M van Dongen, Ulrike Koehl, Jochen Harbott, Martin Schrappe, H B Beverloo, Susanne Schnittger, Olaf Heidenreich, Grigory Tsaur, Jürgen Krauter, T. Klingebiel, Dean A. Lee, C Eckert, Rosemary Sutton, Sze-Fai Yip |
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| Přispěvatelé: | Immunology, Pediatrics, Clinical Genetics, University of Zurich, Marschalek, R |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Cancer Research Oncogene Proteins Fusion Biopsy 2720 Hematology 610 Medicine & health Biology Polymerase Chain Reaction Translocation Genetic Fusion gene Bone Marrow Gene Duplication hemic and lymphatic diseases Acute lymphocytic leukemia medicine Humans 1306 Cancer Research Child neoplasms Recombination Genetic Genetics Acute leukemia Leukemia Chromosomes Human Pair 11 Computational Biology Myeloid leukemia Chromosome Breakage DNA Neoplasm Histone-Lysine N-Methyltransferase Hematology Gene rearrangement medicine.disease Minimal residual disease Neoplasm Proteins Oncology 10036 Medical Clinic Acute Disease Cancer research 2730 Oncology Chromosome breakage Myeloid-Lymphoid Leukemia Protein |
| Zdroj: | Leukemia, 23, 1490-1499. Nature Publishing Group |
| ISSN: | 1476-5551 0887-6924 |
| Popis: | Chromosomal rearrangements of the human MLL gene are associated with high-risk pediatric, adult and therapy-associated acute leukemias. These patients need to be identified, treated appropriately and minimal residual disease was monitored by quantitative PCR techniques. Genomic DNA was isolated from individual acute leukemia patients to identify and characterize chromosomal rearrangements involving the human MLL gene. A total of 760 MLL-rearranged biopsy samples obtained from 384 pediatric and 376 adult leukemia patients were characterized at the molecular level. The distribution of MLL breakpoints for clinical subtypes (acute lymphoblastic leukemia, acute myeloid leukemia, pediatric and adult) and fused translocation partner genes (TPGs) will be presented, including novel MLL fusion genes. Combined data of our study and recently published data revealed 104 different MLL rearrangements of which 64 TPGs are now characterized on the molecular level. Nine TPGs seem to be predominantly involved in genetic recombinations of MLL: AFF1/AF4, MLLT3/AF9, MLLT1/ENL, MLLT10/AF10, MLLT4/AF6, ELL, EPS15/AF1P, MLLT6/AF17 and SEPT6, respectively. Moreover, we describe for the first time the genetic network of reciprocal MLL gene fusions deriving from complex rearrangements. |
| Databáze: | OpenAIRE |
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