Improvement in Diabetic Retinopathy through Protection against Retinal Apoptosis in Spontaneously Diabetic Torii Rats Mediated by Ethanol Extract of Osteomeles schwerinae C.K. Schneid

Autor: Jin Sook Kim, Kyuhyung Jo, IkSoo Lee, Young Sook Kim, Joo-Hwan Kim, Yun Mi Lee, Dong Ho Jung, Chan-Sik Kim, Jung Hyun Kim
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Glycation End Products
Advanced
Male
Apoptosis
Pharmacology
medicine.disease_cause
combination therapy
chemistry.chemical_compound
0302 clinical medicine
spontaneously diabetic Torii (SDT) rat
oxidative stress
Nutrition and Dietetics
advanced glycation end products (AGEs)
Diabetic retinopathy
030220 oncology & carcinogenesis
human retinal microvascular endothelial cells (HRMECs)
Apigenin
Advanced glycation end-product
Osteomeles schwerinae
lcsh:Nutrition. Foods and food supply
Combination therapy
lcsh:TX341-641
endocrinology_metabolomics
Article
Retina
03 medical and health sciences
Downregulation and upregulation
mitochondrial function
medicine
Diabetes Mellitus
Animals
Humans
diabetic retinopathy (DR)
retinal apoptosis
Diabetic Retinopathy
Ethanol
business.industry
Plant Extracts
Endothelial Cells
Retinal
medicine.disease
Rats
adjunctive effect
030104 developmental biology
chemistry
business
Oxidative stress
Food Science
Drugs
Chinese Herbal
Zdroj: Nutrients
Volume 11
Issue 3
Nutrients, Vol 11, Iss 3, p 546 (2019)
ISSN: 2072-6643
DOI: 10.3390/nu11030546
Popis: Retinal apoptosis plays a critical role in the progression of diabetic retinopathy (DR), a common diabetic complication. Currently, the tight control of blood glucose levels is the standard approach to prevent or delay the progression of DR. However, prevalence of DR among diabetic patients remains high. Focusing on natural nutrients or herbal medicines that can prevent or delay the onset of diabetic complications, we administered an ethanol extract of the aerial portion of Osteomeles schwerinae (OSSCE), a Chinese herbal medicine, over a period of 17 weeks to spontaneously diabetic Torii (SDT) rats. OSSCE was found to ameliorate retinal apoptosis through the regulation of advanced glycation end product (AGE) accumulation, oxidative stress, and mitochondrial function via the inhibition of NF-&kappa
B activity, in turn, through the downregulation of PKC&delta
P47phox, and ERK1/2. We further demonstrated in 25 mM glucose-treated human retinal microvascular endothelial cells (HRMECs) that hyperoside (3-O-galactoside-quercetin), quercitrin (3-O-rhamnoside-quercetin), and 2&Prime
O-acetylvitexin (8-C-(2&Prime
O-acetyl-glucoside)-apigenin) were the active components of OSSCE that mediated its pharmacological action. Our results provide evidence that OSSCE is a powerful agent that may directly mediate a delay in the development or disease improvement in patients of DR.
Databáze: OpenAIRE
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