Magnetization transfer imaging in multiple sclerosis treated with alemtuzumab
| Autor: | Tom Button, K Hunter, Daniel J. Tozer, Catherine M. Dalton, Alasdair Coles, David Miller, Alastair Compston, Daniel R. Altmann |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Lesion formation Grey matter Antibodies Monoclonal Humanized Cohort Studies White matter Disability Evaluation Multiple Sclerosis Relapsing-Remitting Sex Factors Nuclear magnetic resonance Tissue damage Image Processing Computer-Assisted medicine Humans Magnetization transfer imaging Magnetization transfer Age of Onset Alemtuzumab business.industry Multiple sclerosis Age Factors Brain medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Neurology Disease Progression Linear Models Female Neurology (clinical) business medicine.drug |
| Zdroj: | Multiple Sclerosis Journal. 19:241-244 |
| ISSN: | 1477-0970 1352-4585 |
| Popis: | The magnetization transfer ratio reflects the integrity of tissue structure, including myelination and axonal density. Mean magnetization transfer ratio fell in 18 untreated patients with multiple sclerosis both in normal appearing grey (-0.25 pu/year, p < 0.001) and white matter (-0.12 pu/year, p = 0.004). Conversely, mean magnetization transfer ratio was stable in 20 alemtuzumab-treated patients (grey matter: -0.01 pu/year, p = 0.87; white matter: -0.02 pu/year, p = 0.51). The gradient difference in grey matter was 0.25 pu/year (p < 0.001) after age-adjustment. These data suggest that in multiple sclerosis alemtuzumab protects against tissue damage in normal-appearing grey matter, perhaps by preventing new lesion formation. |
| Databáze: | OpenAIRE |
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