The evaluation of the effects of steroid treatment on the tumor and peritumoral edema by DWI and MR spectroscopy in brain tumors
| Autor: | Ozkan Tehli, Çağlar Temiz, İlker Solmaz, Cahit Kural, Irgen Hodaj, Gökçe Kaan Ataç, Yusuf Izci |
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| Rok vydání: | 2017 |
| Předmět: |
In vivo magnetic resonance spectroscopy
Pathology medicine.medical_specialty Magnetic Resonance Spectroscopy Brain tumor Brain Edema Glial tumor Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Glioma Edema medicine Humans Dexamethasone medicine.diagnostic_test business.industry Brain Neoplasms Magnetic resonance imaging medicine.disease Diffusion Magnetic Resonance Imaging 030220 oncology & carcinogenesis Surgery Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery medicine.drug Brain metastasis |
| Zdroj: | Neurologia i neurochirurgia polska. 52(4) |
| ISSN: | 0028-3843 |
| Popis: | Objective To investigate the effects of dexamethasone on brain tumor and peritumoral edema by different sequences of magnetic resonance imaging (MRI). Materials and methods MRI was performed in 28 patients with brain tumor. Patients were divided into the 3 groups based on the histological diagnosis; Group I: high-grade glial tumor, Group II: low-grade glial tumor, and Group III: brain metastasis. The measurements of peritumoral edema volume and apparent diffusion coefficient (ADC) values were performed while the peak areas of cerebral metabolites were measured by spectroscopy in groups I and II. The changes in edema volumes, ADC values and cholin/creatine peak areas were compared. Results The volume of peritumoral edema was decreased in groups I and II, but increased in group III after dexamethasone treatment. These changes were not statistically significant for 3 groups. ADC value was decreased in group I and increased in groups II and III. Changes in ADC values were statistically significant. Cholin/creatine peak areas were decreased after dexamethasone in groups I and II, but these changes were also not significant. Conclusion Dexamethasone has no significant effect on the volume of peritumoral edema in glial tumor and metastasis. Moreover, dexamethasone increases the fluid movements in low grade gliomas and metastases, decreases in high grade gliomas. However, more comprehensive clinical studies are needed to show the effects of dexamethasone on brain tumors and peritumoral edema. |
| Databáze: | OpenAIRE |
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