Leukocyte telomere length is inversely associated with arterial wave reflection in 566 normotensive and never-treated hypertensive subjects
| Autor: | Ilkka Pörsti, Mika Kähönen, Terho Lehtimäki, Anna E. Nyman, Kati Vääräniemi, Milja Honkonen, Antti Tikkakoski, Frej Fyhrquist, Outi Saijonmaa, Jenni Koskela, Jukka Mustonen |
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| Přispěvatelé: | Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, Tampere University |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Aging Hemodynamics Blood Pressure Pulse Wave Analysis hemodynamics Cardiography Impedance Biokemia solu- ja molekyylibiologia - Biochemistry cell and molecular biology Young Adult Internal medicine Linear regression medicine Leukocytes Humans Prospective Studies circulatory system Pulse wave velocity Aged Univariate analysis medicine.diagnostic_test business.industry aging Sisätaudit - Internal medicine Telomere Homeostasis Cell Biology Middle Aged telomeres Impedance cardiography medicine.anatomical_structure Blood pressure Hypertension Vascular resistance Cardiology Female Vascular Resistance business Body mass index Research Paper |
| Zdroj: | Aging (Albany NY) |
| Popis: | Telomeres are short segments in chromosome ends, the length of which is reduced during cell lifecycles. We examined the association of mean leukocyte telomere length (LTL) and short telomere proportion (STP) with hemodynamic variables in normotensive and never-treated hypertensive volunteers (n=566, 19-72 years). STP and mean LTL were determined using Southern blotting, and supine hemodynamics recorded using continuous tonometric pulse wave analysis and whole-body impedance cardiography. The analyses were adjusted for age, body mass index (BMI), alcohol use, smoking, plasma chemistry, and estimated glomerular filtration rate (eGFR). In univariate analyses, mean LTL and STP both correlated with age, BMI, eGFR, aortic blood pressure, augmentation index, and pulse wave velocity (p |
| Databáze: | OpenAIRE |
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