Insecticide resistance profiles in malaria vector populations from Sud-Kivu in the Democratic Republic of the Congo
| Autor: | Roch K. Dabiré, Maite Guardiola-Claramonte, Christophe Boëte, Claude C Habamungu, Severin N’do, Koama Bayili, R. Serge Yerbanga, Mahamadi Kientega, Didier A P Kaboré, Dieudonné Diloma Soma, Abdoulaye Diabaté, Bertin Z. Musaka, Adrien Marie Gaston Belem, Janvier B. Bandibabone, Moussa Namountougou, Jean-Bosco Ouédraogo, Ibrahim Sangaré, Jorian Prudhomme, Bantuzeko Chimanuka |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Insecticides Veterinary medicine Mosquito Control Anopheles gambiae 030231 tropical medicine Mosquito Vectors Fenitrothion Insecticide Resistance 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Anopheles Pyrethrins parasitic diseases medicine Animals Humans biology Public Health Environmental and Occupational Health General Medicine Propoxur biology.organism_classification medicine.disease Malaria 030104 developmental biology Infectious Diseases Deltamethrin chemistry Vector (epidemiology) Democratic Republic of the Congo Malathion Parasitology |
| Zdroj: | Transactions of The Royal Society of Tropical Medicine and Hygiene. 115:1339-1344 |
| ISSN: | 1878-3503 0035-9203 |
| Popis: | Background Insecticide resistance has become a widespread problem causing a decline in the effectiveness of vector control tools in sub-Saharan Africa. In this situation, ongoing monitoring of vector susceptibility to insecticides is encouraged by the WHO to guide national malaria control programmes. Our study was conducted from April to November 2018 in Tchonka (Sud-Kivu, Democratic Republic of the Congo) and reported primary data on the resistance status of Anopheles funestus and Anopheles gambiae. Methods Insecticide susceptibility bioassays were performed on wild populations of A. funestus and A. gambiae using WHO insecticide-impregnated papers at discriminating concentration. In addition, PCR was performed to identify mosquito species and to detect kdr and ace-1R mutations involved in insecticide resistance. Results Bioassay results show resistance to all tested insecticides except pirimiphos-methyl, propoxur, fenitrothion and malathion with a mortality rate ranging from 95.48 to 99.86%. The addition of piperonyl butoxide (PBO) increased the susceptibility of vectors to deltamethrin and alpha-cypermethrin by exhibiting a mortality ranging from 91.50 to 95.86%. The kdr mutation was detected at high frequencies (approximately 0.98) within A. gambiae while ace-1R was not detected. Conclusions This study provides useful data on the insecticide resistance profiles of malaria vector populations to better manage vector control. Our results highlight that, despite the high level of resistance, organophosphorus compounds and pyrethroids + PBO remain effective against the vectors. |
| Databáze: | OpenAIRE |
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