Embracing the complexity of matricellular proteins: the functional and clinical significance of splice variation
| Autor: | Natasha J. Hill, Katrina Viloria |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
matricellular QH301-705.5 Computational biology Periostin Biology Bioinformatics General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Cellular and Molecular Neuroscience alternative splice variation 0302 clinical medicine Neoplasms Animals Humans Protein Isoforms Genetic Predisposition to Disease Protein Interaction Domains and Motifs tenascin-c Molecular Targeted Therapy Biology (General) Cell adhesion Gene Genetic Association Studies periostin Thrombospondin Extracellular Matrix Proteins integumentary system Alternative splicing Tenascin C Tenascin General Medicine Extracellular Matrix Alternative Splicing 030104 developmental biology Gene Expression Regulation 030220 oncology & carcinogenesis RNA splicing biology.protein Osteopontin Cell Adhesion Molecules Protein Processing Post-Translational Function (biology) biological Protein Binding |
| Zdroj: | Biomolecular Concepts, Vol 7, Iss 2, Pp 117-132 (2016) |
| ISSN: | 1868-503X 1868-5021 |
| Popis: | Matricellular proteins influence wide-ranging fundamental cellular processes including cell adhesion, migration, growth and differentiation. They achieve this both through interactions with cell surface receptors and regulation of the matrix environment. Many matricellular proteins are also associated with diverse clinical disorders including cancer and diabetes. Alternative splicing is a precisely regulated process that can produce multiple isoforms with variable functions from a single gene. To date, the expression of alternate transcripts for the matricellular family has been reported for only a handful of genes. Here we analyse the evidence for alternative splicing across the matricellular family including the secreted protein acidic and rich in cysteine (SPARC), thrombospondin, tenascin and CCN families. We find that matricellular proteins have double the average number of splice variants per gene, and discuss the types of domain affected by splicing in matricellular proteins. We also review the clinical significance of alternative splicing for three specific matricellular proteins that have been relatively well characterised: osteopontin (OPN), tenascin-C (TNC) and periostin. Embracing the complexity of matricellular splice variants will be important for understanding the sometimes contradictory function of these powerful regulatory proteins, and for their effective clinical application as biomarkers and therapeutic targets. |
| Databáze: | OpenAIRE |
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